摘要
目的研究鼻咽癌放射性黏膜炎早期使用羟考酮控释片的有效性和安全性。方法将入组患者随机分为研究组（轻度组）和对照组（中度组）。所有患者接受根治性放疗。在患者出现放射性黏膜炎时，研究组在轻度疼痛开始使用羟考酮控释片止痛，对照组达到中度疼痛时采用羟考酮控释片治疗。观察两组止痛效果、营养状况与不良反应。结果共154例患者人组，分为研究组与对照组，各77例。研究组完全缓解率、有效率（部分缓解加完全缓解）较好，但差异无统计学意义（均P〉0．05）。研究组无痛或轻度疼痛（疼痛评分≤3分）的时间为（23．86±6．55）d，对照组为（19．84±6．02）d，差异有统计学意义（P〈0．01）。治疗结束时研究组体重下降较少，但差异无统计学意义[（7．40±3．57）％比（8．68±4．18）％，P=O．1611。常见的止痛药相关不良反应为便秘、恶心，呕吐、头晕等，程度为1～2级。两组不良反应发生率和严重程度差异无统计学意义。结论对于放射性黏膜炎，早期采用羟考酮控释片进行干预能够延长无痛或轻度疼痛的时间，但不能显著改善营养状态。
Objective To evaluate the safety and effectiveness of early use of oxycodone control release tablets for radiation mucositis in patients with nasopharyngeal carcinoma. Methods The patients were randomly divided into a study group （mild） and a control group （moderate）. All the patients received radical radiotherapy and got radiation mucositis. Oxycodone control release tablets were given at either mild （the study group） or moderate （the control group） pain levels. The analgesic effects, adverse effects, and nutrition status were compared between the two groups. Results 154 patients were enrolled and equally allocated into a study group and a control group, 77 for each group. The effective rates （complete response and partial response） were 87.0% and 89.6% in the study group and the control group, respectively, with no statistical difference （P=-0.617）. The mild or no pain （numbering rating scores 〈 3） time was （19.84＋6.02） d in the control group and （23.86＋6.55） d in the study group, with a statistical difference （P 〈 0.01）. Patients in both two groups lost their weight. The study group had better nutrition status than the control group, but with no statistical difference [weight loss （7.40^-3.57）% vs. （8.68~4.18）%, P=0.161]. The main adverse reactions included constipation, nausea/vomit, dizzy, and so on; there were no statistical differences in the incidence and levels of adverse reactions between these two groups. Conclusions Early use of oxycodone control release tablets for radiation mucositis in patients with nasopharyngeal carcinoma has longer no pain or mild pain time, but cannot improve nutrition status.
出处
《国际医药卫生导报》
2018年第2期164-167,293,共5页
International Medicine and Health Guidance News
基金
广州医科大学博士启动基金资助项目（N02010C10）
广州市中医药和中西医结合科技项目（20152A011021）
关键词
鼻咽癌
放射治疗
放射性黏膜炎
镇痛治疗
羟考酮
Nasopharyngeal carcinoma
Radiation therapy
Radiation mucositis
Analgesic treatment
Oxycodone
