摘要
胶原蛋白具有强亲水性、优异的生物相容性、弱抗原性和易加工成型等独特的功能特性,已成为最有前途的绿色可再生材料之一。为了克服天然胶原蛋白材料热稳定性差、抗水性差、机械强度低、易酶解和易污染等缺陷,通常采用共价交联法、静电纺丝法、自组装法和相分离法等方法对胶原蛋白进行加工处理。本文首先介绍了胶原蛋白基生物功能材料的4种方法的制备原理,描述了4种方法的研究现状,指出了4种方法各自的优点和缺点,然后比较了4种方法的制备工艺、制备材料的结构和功能差异,最后展望了胶原蛋白基生物功能材料的研究前景。结果表明:胶原蛋白基生物功能材料作为清洁可再生材料在智能纳米药物载体、微型生物反应器、传感器、人造光俘获系统等领域具有广阔的应用前景。
Collagen has become one of the most promising green renewable functional materials due to its strong hydrophilicity,excellent biocompatibility,weak antigenicity,and easy to be processed. In order to overcome the disadvantages of natural collagen material,such as poor thermal stability,poor water resistance,low mechanical strength,easy enzymolysis and easy pollution,the collagen is usually processed by covalent cross-linking,electrospinning,self-assembly and phase separation. Firstly,the principle of four kinds of preparation methods was introduced. The research status of the four preparation methods was described. The advantages and disadvantages of the four methods were pointed out. Then,the preparation process,structure and function difference of the four methods were compared. Finally,the prospect of collagen based biomaterials was reviewed. Results showed that as a clean and renewable material,collagen based biomaterials have broad application prospects in the fields of micro bioreactor,sensor,mart drug delivery system,and artificial light harvesting system.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2018年第2期592-598,共7页
Chemical Industry and Engineering Progress
关键词
蛋白质
胶原蛋白
复合材料
纳米结构
制备
生物工程
protein
collagen
composites
nanostructure
preparation
biological engineering
