摘要
目的评价国产电子挥发罐用于兔七氟醚麻醉的有效性。方法健康清洁级新西兰兔90只，4～5月龄，重2.5～3.5 kg，雌雄不拘，采用随机数字表法分为3组（n＝30）：机械挥发罐组（M组）、国产电子挥发罐组（E组）和Zeus电子挥发罐组（Z组）。M组采用机械挥发罐，挥发罐刻度调至2%，新鲜气流量2 L/min；E组采用BR850国产电子挥发罐，Z组采用Zeus电子挥发罐，吸入七氟醚浓度均为2%；各组均持续吸入2 h。M组采用公式法和称重法计算七氟醚消耗量；Z组和E组采用电子计算法和称重法计算七氟醚消耗量。记录呼气末七氟醚浓度（ETCsev）稳定值、ETCsev达到稳定值的时间，达稳定值后每10 min（T1-T12）记录ETCsev。结果与M组比较，Z组和E组七氟醚消耗量（称重法）减少，ETCsev达到稳定值时间缩短（P〈0.05）；与Z组比较，E组七氟醚消耗量（称重法）增多（P〈0.05），ETCsev达到稳定值时间差异无统计学意义（P〉0.05）；与七氟醚消耗量（称重法）比较，Z组七氟醚消耗量（电子计算法）差异无统计学意义（P〉0.05），E组七氟醚消耗量（电子计算法）增多（P〈0.05）。3组ETCsev稳定值比较差异无统计学意义（P〈0.05）。ETCsev组内和组间比较差异无统计学意义（P〉0.05）。结论国产电子挥发罐实现了吸入麻醉药挥发浓度控制的自动化和精准化，可有效地用于兔七氟醚麻醉，虽然与Zeus电子挥发罐相比，其精准性还有待于进一步提高，但成本明显低廉，兼容性强，具备推广使用价值。
Objective To evaluate the efficacy of domestic electronic vaporizer when used for sevoflurane anesthesia in rabbits.Methods Ninety healthy pathogen-free New Zealand rabbits of both sexes, aged 4-5 months, weighing 2.5-3.5 kg, were divided into 3 groups（n=30 each）using a random number table： mechanical vaporizer group（group M）, domestic electronic vaporizer group（group E）and Zeus electronic vaporizer group（group Z）. In group M, the mechanical vaporizer was used, the sevoflurane vaporizer dial was adjusted to 2%, with the fresh air flow set at 2 L/min.In E and Z groups, BR850 domestic electronic vaporizer and Zeus electronic vaporizer were used, respectively, and the concentration of sevoflurane inhaled was 2%.Sevoflurane was inhaled for 2 h in each group.The formula method and weighing method were used to calculate the consumption of sevoflurane in group M. The electronic calculation method and weighing method were used to calculate the consumption of sevoflurane in Z and E groups.The stable value of end-tidal sevoflurane concentration（ETCsev）and time for ETCsev reaching the stable value were recorded.ETCsev was recorded every 10 min after reaching the stable value（T1-T12）.Results Compared with group M, the consumption of sevoflurane（weighing method）was significantly reduced, and the time for ETCsev reaching the stable value was shortened in Z and E groups（P〈0.05）. Compared with group Z, the consumption of sevoflurane（weighing method）was significantly increased（P〈0.05）, and no significant change was found in the time for ETCsev reaching the stable value in group E（P〉0.05）. Compared with the consumption of sevoflurane（weighing method）, no significant change was found in the consumption of sevoflurane（electronic method）in group Z（P〉0.05）, and the consumption of sevoflurane（electronic method）was significantly increased in group E（P〈0.05）. There was no significant difference in the stable value of ETCsev between the three groups（P〈0.05）.
作者
贺文泉
吕锐
刘畅
陈杨
易斌
鲁开智
He Wenquan;Lyu Rui;Liu Chang;Chen Yaag;Yi Bin;Lu Kaizhi(Department of Surgery and Anesthesiology, First Affiliated Hospital, Third Military Medical University, Choagqing400038, Chin)
出处
《中华麻醉学杂志》
CSCD
北大核心
2017年第12期1520-1523,共4页
Chinese Journal of Anesthesiology
基金
重庆市重点科技计划项目（cstc2014yykfB10005）
关键词
麻醉
吸入
雾化器和汽化器
Anesthesia, Inhalation
Nebulizers and vaporizers
