摘要
目的研究血小板反应蛋白2(TSP-2)联合血清白蛋白(ALB)对川崎病患儿冠脉损害的早期预测价值。方法将我院2014年4月至2017年7月收治的68例川崎病患儿作为川崎病组,同期发热非川崎病患儿34例与健康儿童34例作为发热组和健康组。川崎病组根据超声心动图表现分为冠脉扩张组与非冠脉扩张组。所有研究对象于同一时间取清晨空腹血离心进行实验室指标(ESR、ALT、AST、CRP、WBC)浓度的检测,酶联免疫吸附法检测TSP-2、TSP-1的浓度。同时绘制ROC曲线,分析TSP-2联合ALB对冠脉扩张的预测价值。结果川崎病组血浆TSP-2水平为(33.79±6.86)μg/L,明显高于发热组(21.471±4.94)μg/L和健康组(16.59±1.69)μg/L,差异有统计学意义(F=126.86,P<0.01)。川崎病组血浆TSP-1水平为(11.27±4.28)μg/L,明显高于发热组(6.73±2.78)μg/L和健康组(3.36±1.11)μg/L,差异有统计学意义(F=66.02,P<0.01)。冠脉扩张组血浆TSP-2水平为(35.32±7.68)μg/L,非冠脉扩张组为(30.31±5.57)μg/L,两组比较差异有统计学意义(t=3.06,P<0.01)。TSP-2单独预测冠脉扩张ROC曲线下面积为0.704,联合白蛋白ROC曲线下面积为0.770。结论 TSP-2水平的升高能够早期预测诊断川崎病并发冠脉损伤,TSP-2升高联合血清ALB降低更具诊断价值。
Objective To investigate the predictive value of thrombospondin-2 combined with serum albumin in children with coronary artery dilatation secondary to Kawasaki disease. Methods Totally 68 children with Kawasaki disease hospitalized in our hospital from April 2014 to February 2017 were enrolled as Kawasaki disease group. 34 fever children with non-Kawasaki disease and 34 healthy children were selected as fever group and healthy group. Children in Kawasaki disease group were divided into coronary artery dilatation group and non-coronary artery dilatation group according to the results of echocardiography. All subjects were taken the early morning fasting blood centrifugation for the defection of laboratory indicators （ ESR, ALT, AST, CRP, and WBC） concentration, enzyme-linked immunosorbent assay was used to measure the levels of thrombospondin-1 （ TSP-1 ） and TSP-2 in plasma of each group. Receiver operating characteristic （ROC） curve was painted for evaluating the predictive value of TSP-2. Results The plasma level of TSP-2 in Kawasaki disease group was higher than that of fever group and healthy group [ （ 33.79 ± 6. 86 ） g/L vs. （ 21.47 ± 4. 94 ） g/L, （ 33.79 ± 6. 86 ） g/L vs. （ 16. 59 ±1.69 ） g/L ] , the difference being statistically significant （ F = 126. 86,P 〈 0. 01 ）. The plasma level of TSP-1 in Kawasaki disease group was higher than that of fever group and healthy group [ （ 11.27 ± 4. 28 ） g/L vs. （ 6. 73 ± 2. 78 ） g/L, （ 11.27 ± 4. 28 ） μg/L vs. （ 3.36 ± 1. 11 ） g/L ], the difference being statistically significant （F--66. 018, P 〈 0. 01 ）. The plasma level of TSP-2 in coronary artery dilatation group was higher than that of non-coronary artery dilatation group [ （ 35.32 ±7. 676 ） μg/L vs. （ 30. 31 ± 5. 571 ） g/ L] , there being significant difference between the two groups （t = 3.06, P 〈 0. 001 ）. Regarding the predictive effect of TSP-2 for coronary artery dilatation, the area under the ROC curve was 0. 704, while the are
出处
《实用药物与临床》
CAS
2018年第1期43-46,共4页
Practical Pharmacy and Clinical Remedies
基金
河南省教育厅自然科学计划研究项目(2011A310004)
