摘要
目的分析原发性干燥综合征(PSS)合并间质性肺病的临床特点。方法选取2009年1月至2016年12月风湿免疫科住院的PSS患者291例,其中合并间质性肺病(ILD)90例(ILD组),不合并间质性肺病(非ILD组)201例。分别比较两组患者的临床表现和实验室检查。结果与非ILD组比较,ILD组患者病程较长(t=3.080,P=0.003),年龄偏大(t=4.703,P=0.000);两组患者性别无统计学差异(χ2=3.098,P=0.078)。伴有口干症状的PSS患者更易合并ILD(χ~2=4.288,P=0.038);合并ILD的PSS患者更易出现肺动脉高压(χ2=24.695,P=0.000);而两组患者在乏力、眼干、猖獗齿、腮腺炎、舌痛、皮疹、关节痛、肌痛、肾脏受累、胸腔积液及血液系统受累诸方面差异无统计学意义(P均>0.05)。伴有高水平C反应蛋白(CRP)的PSS患者更易合并ILD(Z=2.535,P=0.011);两组患者在抗SSA抗体、抗SSB抗体、ESR、IgA、IgM、IgG、类风湿因子定量及抗环瓜氨酸肽抗体水平的差异均无统计学意义(P均>0.05)。结论病程长、年龄偏大的PSS患者更易合并ILD;伴有口干表现及较高CRP水平的PSS患者容易出现ILD;合并ILD的PSS患者更易出现肺动脉高压。
Objective To analyze the clinical characteristics of primary Sj6gren＇s syndrome （PSS） accompanied with interstitial lung disease（ILD）. Methods Out of 291 PSS patients selected between January 2009 and December 2016 were divided into ILD group （ PSS patients with ILD, n = 90 ） and non-ILD group （ patients without ILD, n = 201 ）. The clinical manifestations and laboratory examinations were observed and compared between two groups. Results Compared with non-ILD group, the course of disease was longer （ t = 3.080, P = 0. 003 ）, and the age was older （ t = 4. 703, P = 0.000）in ILD group. There was no significant difference in sex（χ^2 = 3.098, P = 0.078）. The PSS patients who accompanied with xerostomia were more likely to combine with ILD （χ^2 = 4. 288, P = 0. 038 ）, and the pulmonary arterial hypertension was more likely to occur in ILD group （χ^2 = 24. 695, P = 0. 000 ）. There were no statistical differences in clinical manifestation of fatigue, xerophthalmia, rampant tooth, mumps, glossalgia, rash, arthralgia, myalgia, renal involvement,pleural effusion and blood system involvement between two groups （ all P 〉 0. 05 ）. The PSS patients who accompanied with high level of C-reactive protein （CRP） were more likely to combine with ILD（Z = 2. 535, P = 0. 011 ）. There were no statistical differences in anti-SSA antibody, anti-SSB antibody, the level of erythrocyte sedimentation rate, immunoglobulin A （ IgA）, IgM, IgG, rheumatoid factor and anti-cyclic citrullinated peptide antibody between two groups （ all P 〉 0. 05）. Conclusions ILD is prone to occur in PSS patients with longer course of disease, older age, xerostomia and high level of CRP. and PSS patients with 1LD were more prone to have pulmonary hypertension.
出处
《中国临床研究》
CAS
2018年第1期125-127,共3页
Chinese Journal of Clinical Research
关键词
干燥综合征
间质性肺病
肺动脉高压
口干
C反应蛋白
Primary Sjsgren＇s syndrome
Interstitial lung disease
Pulmonary arterial hypertension
Xerostomia
C- reactive protein
