摘要
目的探讨研究NSE和ProGRP水平与小细胞肺癌病理分期的相关性。方法选取接受化疗的138例小细胞肺癌患者为SCLC组。另取肺部良性疾病患者30例和健康体检者30例作为对照。所有研究对象均进行NSE与ProGRP检测,对比不同组及不同病理分期间NSE和ProGRP的水平差异,并对两种标志物间的检测结果进行相关性分析。结果正常对照组,肺部良性疾病组及SCLC组三组间NSE和ProGRP水平存在显著性差异(P<0.05);肺部良性疾病组与正常对照组间差异无统计学意义(P>0.05),SCLC组显著高于肺部良性疾病组与正常对照组(P<0.05)。LDSCLC组、ED-SCLC组、SCLC组三组间NSE和ProGRP水平存在显著性差异(P<0.05);ED-SCLC组高于其他两组(P<0.05),LD-SCLC组低于其他两组(P<0.05)。不同病理分期间NSE、ProGRP水平存在显著性差异(P<0.05),病理分期越高,NSE、ProGRP水平越高;ProGRP与NSE的水平呈显著正相关(P<0.05)。结论 NSE和ProGRP均为SCLC较敏感的肿瘤标志物,在SCLC的早期诊断、病理分期等方面具有重要意义,两者联合应用可在SCLC的诊疗过程中发挥重要价值。
Objective To study the correlation of NSE and ProGRP level with different pathological stages of small cell lung cancer （SCLC）. Methods 138 SCLC patients treated with chemotherapy were selected. 30 patients with benign pulmonary disease and 30 healthy check-ups were also selected. The NSE and ProGRP level of different groups was detected. The correlation of NSE and ProGRP level with the different pathological stages of SCLC was analyzed. Results NSE and ProGRP level in the control group, benign pulmonary disease group and SCLC group were significantly different （ P 〈 0.05 ） ; the NSE and ProGRP lev- el in benign pulmonary disease group and the control group was not significantly different （ P 〉 0.05 ） ; the NSE and ProGRP level in SCLC group was significantly higher than benign pulmonary disease group and control group （P 〈0.05） ;the NSE and ProGRP level of LD-SCLC group, ED-SCLC group and SCLC group was significantly different （ P 〈 0.05 ） ; the NSE and ProGRP level of ED-SCLC group were higher than LD-SCLC group and SCLC group （ P 〈 0.05 ） ; NSE and ProGRP level at different pathological stages were significantly different （ P 〈 0.05 ） ; the higher the pathological stage was, the higher the NSE and ProGRP level was. The NSE and ProGRP level were positively correlated with the pathological stages. （P 〈 0.05 ）. Conclusion NSE and ProGRP level are the tumor marker of SCLC. It is of great importance and great value in the early diagnosis and pathological stages of SCLC. The combined examination of NSE and ProGRP level is more important.
出处
《实用癌症杂志》
2018年第2期177-180,共4页
The Practical Journal of Cancer
