摘要
目的:分析舌下脱敏治疗(SLIT)前后变应性鼻炎对儿童生活质量的影响以及儿童患者生活质量的差异。方法:选取儿童变应性鼻炎脱敏治疗患者50例,用VAS评分和儿童鼻结膜炎生活质量量表(RQLQ)评估治疗前后儿童鼻结膜炎相关生活质量。结果:脱敏治疗组患者治疗前后显效20例,有效13例,无效17例,总有效率为66%。各个观察时间节点(治疗前及治疗后半年、1年、2年)的Multi-VAS评分和Uni-VAS评分比较均差异有统计学意义(P<0.05)。生活质量问卷各具体项目各个观察节点比较,除鼻部症状治疗后1年与2年、眼部症状治疗后半年与1年、行为问题治疗后半年与1年、行为问题治疗后半年与2年、情感治疗后半年与1年,差异无统计学差异外(P>0.05),其余均差异有统计学意义(P<0.05)。患儿在对症治疗药物的使用上,各个时间节点药物评分比较均差异有统计学意义(P<0.05)。各个时间节点患者的药物评分与总体生活质量评分呈正相关性。结论:舌下脱敏治疗可以改善患儿的症状,提高患儿的生活质量,减少变应性鼻炎对症药物的使用。
Objective：To analyze the impact of sublingual immunotherapy（SLIT）on the quality of life in children with allergic rhinitis.Method：Fifty children with allergic rhinitis who have received sublingual immunotherapy were enrolled in this study.Quality of life was evaluated via measurement of VAS score and rhinoconjunctivitis quality of life questionnaire（RQLQ）before and after treatment.Result：Twenty patients after treatment had complete remission,13 cases were partly alleviated and 17 cases had no response.The total effective rate was 66%.The Multi-VAS scores and Uni-VAS scores in each observation time point（at half a year,one year,two years after treatment）had statistically significant difference compared with that of pre-treatment with SLIT（P0.05）.According to RQLQ scores,the quality of life,nasal symptoms,conjunctiva symptoms,non-nasal（ocular）symp-toms,behaviors and emotional responses were greatly improved in each time point compared with that of pretreatment（P0.05）.Symptomatic treatment scores in each time point after treatment were significantly different and had a positive correlation with the scores of RQLQ（P0.05）.Conclusion：SLIT can improve the nasal allergic symptoms,children＇s life quality and reduce the use of symptomatic treatment medicines.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2018年第2期95-98,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
国家自然科学基金青年基金(No:31400856)
深圳市科创委基金(No:JCYJ20160429091935720)
龙岗区科创委基金(No:20160607142024828
No:20160607144031484
No:20160607141853516)
深圳市卫人委基金(No:201502016)
关键词
鼻炎
变应性
儿童
脱敏治疗
生活质量
rhinitis, allergic
children
desensitization therapy
quality of life
