摘要
采用2015版W H O肝癌组织学分类方法,对临床上犬和猫的肝癌进行病理学分析。通过石蜡切片的常规染色（HE染色）及免疫组织化学方法进行组织学鉴定。犬的病理学检查结果为肝脏组织的外部多处坏死出血与肝硬化。我们进一步应用HE染色的方法对肝组织进行染色,观察到其病理改变为细胞有异型,〉3层的细胞排列成柱状,梁索状和腺泡状,细胞异型性明显,核仁显著,最后确诊为为肝细胞癌。猫的病理学检查结果为胆管上的肥大部分,胆管的纤维组织显著增加,是狭窄胆管胞膛,黏膜红色。在狭窄的部位,胆管扩张。胆管上皮增生管状腺,纤维增加,淋巴细胞浸润。胃、十二指肠、结肠黏膜固有层淋巴细胞浸润,纤维分生固有层淋巴细胞浸润。最后确诊为肝胆管癌。
Histopathological analysis of HCC in dogs and cats was carried out by Hepatocellular Carcinoma Classification published by WH0 in 2015. Histological identification was performed by the conventional staining（BEstaining）and immunohistochemistry. The external liver tissue＇s necrotic bleed- ing site and the cirrhosis were observed by pathological examination. The liver staining was further performed by HEstaining,and its pathological changes were observed. More than 3 layers of cells were arranged in a columnar,beam-like and alveolar,and cell abnormalities was significant,and nucleolus was significant,and finally it was diagnosed as hepatocellular carcinoma. In pathological examination for cat,the fibrous tissue of the bile duct,which was significantly increased,was composed of narrow bile duct cells with mucosal red. Bile duct was dilated in the narrow part. Tubular glandshyperplasia was in biliary epithelial cells,fibrosis and lymphocyte infiltrationoccured. The mucosa lamina pro- pria lymphocyte infiltration in stomach,duodenum and colon occured too. The fibrous meridien was in- filtrated by lymphocytes. It was finally diagnosed as hepatocellular carcinoma.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2018年第1期107-113,共7页
Chinese Veterinary Science
基金
黑龙江省自然科学基金项目(C201438)
关键词
肝癌
病理学诊断
免疫组织化学
liver cancer
pathology diagnosis
immunohistochemistry
