摘要
目的探讨富血小板血浆(PRP)复合移植骨用于肱骨髁部骨缺损的修复效果。方法选取2012年1月至2015年12月在安康市中心医院行自体骨移植治疗的肱骨髁部骨缺损的135例患者,按照治疗方法的不同分成PRP复合组(n=69)和传统组(n=66),分别给予富血小板血浆复合自体骨移植治疗和自体骨移植治疗,比较其手术时间、住院时间、伤口愈合情况、骨折愈合情况、术后1年肘关节活动度,并绘制Kaplan-Meier生存曲线反映2组患者骨性愈合的情况,进行log-rank检验比较其结果。结果 2组患者在手术时间、住院时间、伤口愈合情况和术后1年肘关节活动度方面差异均无统计学意义(P>0.05),但PRP复合组的平均伤口愈合时间(3.8±0.72)周和骨性愈合时间(18.8±3.50)周均明显短于传统组的伤口愈合时间(6.4±0.58)周和骨性愈合时间(22.7±1.55)周,差异均有统计学意义(P=0.000),PRP复合组骨性愈合情况的Kaplan-Meier生存曲线也显著优于传统组。结论 PRP能够促进肱骨髁部骨缺损患者自体骨移植后骨折愈合的速度,有利于肘关节功能的恢复。
Objective To investigate the effect of platelet-rich plasma（ PRP） combined with bone graft in the treatment of humeral condylar bone defect. Methods A total of 135 patients with humeral condylar bone defect in Ankang central hospital from January 2012 to December 2015 were divided into the PRP combined group（ n = 69） and the conventional group（ n = 66） according to the order of admission time. The patients of PRP combined group were treated with platelet-rich plasma combined with autologous bone graft,and patients of conventional group received autologous bone graft,respectively. The surgery time,hospitalization time,wound healing,fracture union and the motion of elbow joint at postoperative 1 year between two groups were compared. The Kaplan-Meier survival curve was used to reflect the bone healing in both groups,and the log-rank test was used to compare the result. Results There was no statistically significant difference in the surgery time,hospitalization time,wound healing and motion of elbow joint at postoperative 1 year between the two groups（ P〈0. 05）. But the average time of wound healing（ 3. 8 ± 0. 72） weeks and the time of bone union（ 18. 8 ± 3. 50） weeks in PRP combined group were significantly shorter than（ 6. 4 ± 0. 58） weeks and（ 22. 7 ± 1. 55） weeks in the conventional group（ P = 0. 000）,the differences were significant. The KaplanMeier survival curve of the bone union in the PRP combined group was also significantly better than that in the conventional group. Conclusion PRP can promote the healing of fracture in patients with humeral condylar bone defect after autologous bone graft,which contributes to the recovery of elbow function.
出处
《局解手术学杂志》
2018年第1期20-24,共5页
Journal of Regional Anatomy and Operative Surgery
基金
河南省教育厅年度自然科学研究计划项目(2011A320015)
关键词
富血小板血浆
自体骨移植
肱骨髁部
骨缺损
platelet rich plasma
autogenous bone graft
humeral condyle
bone defect
