摘要
目的观察加减知柏地黄汤治疗肾阴虚火旺证多囊卵巢综合征(PCOS)高雄激素血症(HA)的临床疗效。方法将45例肾阴虚火旺证HA的PCOS患者随机分为中药组30例和达英组15例。中药组自月经周期第5天起口服加减知柏地黄汤,连服28天;达英组按常规服法(月经周期第5天起,2 mg/天,连服21天后停药7天)。观察治疗前后血清睾酮(T)、促黄体生成素(LH)、卵泡刺激素(FSH)、泌乳素(PRL)、雌二醇(E2)、肝功能(ALT、AST)和痤疮评分、月经周期评分、月经量评分、基础体温(BBT),计算BBT双相率。结果(1)与治疗前比较,治疗后两组血清T水平显著下降(P<0.01),两组治疗后比较,差异无统计学意义(P>0.05)。与治疗前比较,达英组治疗后血清LH水平显著降低(P<0.01)。两组治疗前后E2、FSH、PRL水平比较,差异均无统计学意义(P>0.05);(2)与治疗前比较,治疗后两组痤疮评分和月经周期评分均明显下降(P<0.05)。治疗后两组组间比较,痤疮评分差异无统计学意义(P>0.05),达英组月经周期评分较中药组明显降低(P<0.01)。两组月经量评分治疗前后比较,差异无统计学意义(P>0.05);(3)中药组7例BBT出现双相,基础体温双相率为23.3%(7/31),达英组无双相体温;(4)与治疗前比较,两组治疗后ALT、AST均差异均无统计学意义(P>0.05)。结论加减知柏地黄汤具有改善肾阴虚火旺证PCOS合并HA患者的临床症状,有一定促进患者恢复自发排卵的作用,对肝功能未见不良影响。
Objective To observe the curative effect of Modified Zhibai Dihuang Decoction （MZBDHD） to treat polycystic ovary syndrome （PCOS） hyperandrogenism （HT） patients with yin deficiency induced fire hyperactivity syndrome （YDIFHS）. Methods Totally 45 PCOS HT patients with YDIFHS were randomly assigned to the MZBDHD group （30 cases） and the Diane-35 group （DG, 15 cases）. Patients in the MZBDHD group took MZBDHD from the 5th day of menstrual cycle for 28 successive days, while those in the DG group took Diane-35 according to routine methods （starting from the 5th day of menstrual cycle at 2 mg per day for 21 successive days, and then with an interval of 7 days）. Levels of serum testosterone （T）, luteinizing hormone （LH）, follicle stimulating hormone （FSH）, prolactin （PRL）, estrogen （E2）, liver functions （ALT and AST）, and ache score （Rosenfield score）, menstrual cycle score, menstrual flow score, basal body temperature （BBT） were observed before and after treatment. Biphasic rate of BBT was calculated. Results （1） Compared with before treatment, serum T level significantly decreased in the two groups （P 〈0.01 ）, but with no statistical difference between the two groups （P 〉0.05）. Compared with before treatment, serum LH level decreased significantly in the DG group after treatment （P 〈0.01 ）. There was no statistical difference in levels of serum E2, FSH, or PRL between the two groups （P 〉0.05）. （2） Compared with before treatment, acne score and menstrual cy- cle score were significantly lower in the two groups （P 〈0.05）. There was no statistical difference in acne score between the two groups after treatment （P 〉0.05）, The menstrual cycle score was obviously lower in the DG group than in the MZBDHD group （P 〈0.01 ）. There was no statistical difference in menstrual flow score between the two groups after and before treatment （P 〉0.05）. （3） Biphasic BBT occurred in 7 cases of the MZBDHD group, with the b
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2018年第1期29-32,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.81674011)
关键词
多囊卵巢综合征
高雄激素血症
肾阴虚火旺
加减知柏地黄汤
polycystic ovary syndrome
hyperandrogenism
yin deficiency induced fire hyperactivity syndrome
Modified Zhibai Dihuang Decoction
