摘要
目的比较宫颈癌根治术后患者行盆腔三维适形放疗(3-dimensional conformal radiotherapy,3DCRT)与调强放疗(intensity modulated radiotherapy,IMRT)的效果与安全性。方法宫颈癌根治术后行放疗患者105例,采用倾向配比评分法进行配对分析后选取56例患者,其中28例行3DCRT(3DCRT组),28例行IMRT(IMRT组),随访观察2组3a生存率、3a复发转移率,记录不良反应发生情况。结果 3DCRT组3a生存率(83.4%)、3a复发转移率(23.5%)与IMRT组(86.5%、17.8%)比较差异均无统计学意义(P>0.05);3DCRT组消化系统、泌尿系统急性不良发应发生率及消化系统慢性不良反应发生率均高于IMRT组(P<0.05),急性血液学及慢性泌尿系统不良反应发生率与IMRT组比较差异无统计学意义(P>0.05)。结论宫颈癌根治术后行3DCRT与IMRT均具有较好疗效,但应用IMRT可减轻不良反应。
Objective To compare the effect and safety of pelvic three-dimensional conformal radiotherapy （3DCRT） and intensity-modulated radiotherapy （IMRT） after radical hysterectomy in patients with cervical cancer. Methods In 105 patients receiving radiotherapy for cervical cancer after radical hysterectomy, 56 patients were selected by propensity score matching, in which 28 patients underwent 3DCRT （3DCRT group） and 28 patients underwent IMRT （IMRT group）. The 3-year survival rate, 3-year relapse and metastasis rate, and the adverse reactions were observed and recorded in two groups. Results There were no significant differences in the 3-year survival rate and 3-year relapse and metastasis rate between 3DCRT group （83.4%, 23.5%） and IMRT group （86.5%, 17.8%） （P〈0. 05）. The incidences of the acute adverse reactions of digestive system and urinary system and chronic adverse reactions of digestive system were significantly higher in 3DCRT group than those in IMRT group （P〈0.05）, and there were no significant differences in the incidences of acute hematologic toxicity and chronic adverse reaction of urinary system between two groups （P〈 0.05）. Conclusion Both 3DCRT and IMRT are effective for cervical cancer after radical hysterectomy, and IMRT can alleviate the adverse reactions.
出处
《中华实用诊断与治疗杂志》
2018年第1期84-86,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省科技攻关计划项目(142102310411)
关键词
宫颈癌
三维适形放疗
调强放疗
总生存期
不良反应
Cervical cancer
three-dimensional conformal radiotherapy
intensity modulated radiotherapy
overall survival
adverse reaction
