摘要
目的探究妊娠剧吐与多种不良围产结局的相关性。方法检索Pub Med、Web of Science、Cochrane、Embase、中国知网(CNKI)、万方、维普等数据库2011年1月至2017年1月有关妊娠剧吐与不良围产结局相关性的文献。提取相关文献的原始数据,对纳入文献采用Newcastle-Ottawa Scale(NOS)评价标准进行质量评价,使用Revman 5.2软件进行OR值、异质性及发表性偏倚的相关统计学分析。结果纳入14个研究,共计3 566 997例孕产妇。荟萃分析结果显示,妊娠剧吐会增加低出生体重儿、小于胎龄儿和早产儿的发生率(低出生体重儿:OR=1.45,95%CI:1.06~1.97,P=0.02;小于胎龄儿:OR=1.27,95%CI:1.04~1.57,P=0.02;早产儿:OR=1.29,95%CI:1.06~1.57,P=0.01),而与新生儿Apgar评分<7(5 min)、死胎、妊娠期糖尿病和妊娠期高血压或子痫前期的发生无显著相关。结论妊娠剧吐与低出生体重儿、小于胎龄儿及早产儿等不良围产结局有关,应及时监控或治疗以降低此类不良结局的发生风险。
Objective To investigate the correlation between hyperemesis gravidarum and adverse perinatal outcomes. Methods Studies that relating to the correlation between hyperemesis gravidarum and adverse perinatal outcomes were searched in PubMed, Web of Science, Cochrane, Embase, CNKI Data, Wan Fang Data and VIP Data etc. （from January 2011 to January 2017）. The quality of included case-control studies or cohort studies was evaluated, and Meta-analysis was performed with RevMan 5.2 software. Results A total of 14 studies were included, involving 3 566 997 women in observation. Meta Analysis results display that the hyperemesis gravidarum will increase the risk of low birth weight infants（ OR = 1. 45, 95% Cl 1. 06 - 1. 91, P = 0 . 0 2 ） , small for gestational age（ OR = 1. 27？ 95% Cl： 1. 04 -1. 57, P = 0.02） and pretenn（ OR = l . 29, 95% Cl： 1. 06 - 1. 57, P = 0 .0 1 ） , but had no significant correlation with the incidence of neonatal Apgar score 〈7（5 min）, stillbirth, gestational diabetes and gestational hypertension or pre-eclampsia. Conclusions Hyperemesis gravidarum is associated with adverse perinatal outcomes such as low birth weight infants, small for gestational age and pretenn, and should be monitored or treated in a timely manner to reduce the risk of adverse outcomes.
出处
《妇产与遗传（电子版）》
2017年第4期21-26,共6页
Obstetrics-Gynecology and Genetics (Electronic Edition)
关键词
妊娠剧吐
不良围产结局
META分析
Hyperemesis gravidarum
Adverse perinatal outcomes
Meta-analysis
