摘要
公元1世纪,希腊医生阿莱泰乌斯首先提出运动诱发型哮喘（exercise-induced asthma,EIA）的概念,继而科学家们开始研究干冷空气（cold dry air,CDA）对人体的影响。CDA可引发流涕、鼻塞等鼻部症状,鼻部黏膜的这种状态被称为非特异性鼻高反应性（nonspecific nasal hyperreactivity,NHR）。近年来,随着对非变应性鼻炎（non allergic rhinitis,NAR）机制方面的研究逐渐深入,发现NHR是NAR的重要临床特征。
Nonspecific nasal hyperreactivity（NHR）has been widespread observed in patients with allergic rhinitis（AR）and nonallergic rhinitis（NAR）.As a clinical hallmark,NHR is more common in patients with NAR.The cold dry air（CDA）can stimulate nasal symptoms such as rhinorrhea and nasal obstruction,and the CDA provocation test can be used as a reliable objective method to evaluate NHR.The mechanism of CDA-induced nasal symptoms is very complicated and thus it has not yet been fully illuminated.The innervation of the nasal nerves includes sensory nerve（trigeminal ganglion）,sympathetic nerve（superior cervical ganglion）and parasympathetic nerve（sphenopalatine ganglion）.CDA innervation may also be associated with these nerves and associated signal pathway.Recently,general attention has been focused on the transient receptor potential（TRP）channel,including TRP vanilloid-1（TRPV1）and TRP ankyrin-1（TRPA1）.More relevant researches are needed to further clarify the mechanism.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2018年第1期71-76,共6页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
科技部国家重点研发计划(No:2016YFC20160905200)
教育部创新团队发展计划(No:IRT13082)
国家自然科学基金重点项目(No:81630023)
国家自然科学基金重点国际合作研究项目(No:81420108009)
国家自然科学基金青年基金项目(No:81400444)
