摘要
瞬时感受器电位(TRP)家族中TRPV 1、TRPV 2、TRPV 3、TRPV 4、TRPM 4、TRPM 5、TRPA 1能够感受温度变化,其中TRPV 1、TRPV 2、TRPV 3、TRPV 4、TRPM 4、TRPM 5能感受温热刺激。艾灸主要通过温热效应来产生作用,因此,以TRP家族中感受温热刺激的成员为切入点,研究艾灸作用机制存在一定的可行性。本文总结感受温热刺激的TRP各自温度激活特征及艾灸温热刺激产生的不同特点,分析两者之间相关性,同时结合艾灸作用的局部效应特点,探讨艾灸局部启动机制及其后产生的级联效应机制研究思路。
Of the mammalian transient receptor potential（TRP） superfamily members,transient receptor potential vanilloid 1（TRPV 1）,TRPV 2,TRPV 3,TRPV 4,melastatin transient receptor potential（TRPM） 4,TRPM 5,and TRP ankyrin 1（TRPA 1）,are mostly permeable to both monovalent and divalent cation channels and are able to sense to changes of the temperature.Cutaneous TRPV 1,TRPV 2,TRPV 3,TRPV 4,TRPM 4 and TRPM 5 are sensitive to warm stimulation.Moxibustion,a type of physical thermal stimulus,can bring forth some curative effects after applying to certain acupoints for a period of time.Therefore,it is possible to reveal the underlying mechanisms of moxibustion in improving some related clinical disorders through studying activities of transient receptor potential family members.In the present paper,the authors summarize various characteristics of the activated TRP family members in the cutaneous tissue.Moreover,the authors also put forward some researching ideas about the local triggering mechanism of moxibustion stimulation and the resultant cascading effects by combining with its characters of local special responses in experimental studies.
出处
《针刺研究》
CAS
CSCD
北大核心
2012年第2期151-154,160,共5页
Acupuncture Research
基金
国家重点基础研究发展计划(No.2009CB522903)
国家自然科学基金(No.81102655)
四川省教育厅(No.09ZB018)资助
关键词
瞬间感受器电位
艾灸疗法
温热刺激
研究思路
Transient receptor potential
Moxibustion therapy
Thermal stimulation
Researching ideas
