摘要
目的:探讨益气养阴方联合放疗对晚期肺癌患者肿瘤负荷及抗肿瘤免疫应答的影响。方法:选择在本院确诊并接受治疗的晚期非小细胞肺癌患者78例,回顾治疗方案并将所有患者分为接受单纯放化疗的常规组41例、在放化疗基础上加入益气养阴方联合治疗的益气养阴方组37例。对比两组治疗前后血清中肿瘤标志物、Th1/Th2细胞因子、Th17/Treg细胞因子含量的差异。结果:治疗后,益气养阴方组血清中肿瘤标志物CA15-3、Cyfra21-1、HSP90α、CEA的含量较常规组低;血清中Th1细胞因子IFN-γ、IL-2的含量较常规组高,Th2细胞因子IL-4、IL-5的含量较常规组低;血清中Th17细胞因子IL-17、IL-23及Treg细胞因子IL-10、TGF-β的含量较常规组低。结论:晚期非小细胞肺癌患者在常规放化疗基础上加入益气养阴方联合治疗,可有效降低肿瘤负荷并优化抗肿瘤免疫功能。
Objective:To investigate the effects of Yiqi Yangyin Prescription combined with radiotherapy on the tumor load and anti-tumor immune response of patients with advanced lung cancer.Methods:A total of 78 patients with advanced nonsmall cell lung cancer who were diagnosed and treated in our hospital between August 2015 and January 2017 were reviewed and then divided into the routine group(n=41)who received chemoradiotherapy alone and the Yiqi Yangyin Prescription group(n=37)who received chemoradiotherapy combined with Yiqi Yangyin Prescription therapy.The differences in serum levels of tumor markers,Th1/Th2 cytokines and Th17/Treg cytokines were compared between the two groups before and after treatment.Results:After treatment,serum tumor markers CA15-3,Cyfra21-1,HSP90αand CEA levels of Yiqi Yangyin Prescription group were lower than those of routine group;serum Th1 cytokines IFN-γand IL-2 levels were higher than those of routine group while Th2 cytokines IL-4 and IL-5 levels were lower than those of routine group;serum Th17 cytokines IL-17 and IL-23 as well as Treg cytokines IL-10 and TGF-βlevels were lower than those of routine group.Conclusion:Routine chemoradiotherapy combined with Yiqi Yangyin Prescription therapy can effectively reduce the tumor load and optimize the anti-tumor immune function in patients with advanced non-small cell lung cancer.
出处
《海南医学院学报》
CAS
2018年第1期75-78,共4页
Journal of Hainan Medical University
基金
河北省科技计划项目(162777186)~~
