摘要
目的分析双歧三联活菌片联合思密达对腹泻患儿IgA、IgG及CD4/CD8指标及症状改善的影响,以探讨药物作用机制。方法选择2014年2月—2017年2月收治的腹泻患儿100例,随机分为对照组与观察组各50例。患者均进行常规治疗,根据患儿的临床表现给予降温、静脉补液、纠正电解质平衡、补充维生素等治疗。对照组在此基础上给予双歧三联活菌片治疗,观察组使用双歧三联活菌片联合思密达进行治疗。比较两组免疫功能、症状改善情况及疗效。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组有效率96.9%高于对照组82.0%(P<0.05)。两组治疗后IgA、IgG及CD4/CD8均高于治疗前(均P<0.05),且观察组IgA、IgG及CD4/CD8[(1.84±0.91)g/L、(14.75±0.87)g/L、(1.76±0.72)]高于对照组[(1.29±0.63)g/L、(10.27±0.94)g/L、(1.33±0.45)](均P<0.05)。观察组在脱水纠正、退热、腹痛消失和大便恢复正常方面均优于对照组,差异有统计学意义(均P<0.05)。结论双歧三联活菌片联合思密达治疗小儿腹泻可增强患儿的免疫功能,有效改善患儿症状,进而提高临床疗效。
Objective To analyze the effect of Jinshuangqi tablets combined with Smecta on IgA, IgG, CD4/CD8 index and symptoms of pediatric diarrhea so as to explore the mechanism of the treatment method. Methods A total of 100 children with diarrhea collected from February 2014 to February 2017 were randomly divided into control group and observation group, 50 cases in each group. Both groups were routinely treated,Control group received Jinshuangqi tablets injection while the observation group used Jinshuangqi tablets combined with Smecta treatment. The immune function, symptom improvement and curative effect were compared between the two groups. Measurement data uses t test and count data uses Z2 test, P〈0.05 is considered statistically significant.Results The effective rate of observation group was 96.9% ,higher than that of the control group 82% （P〈0.05）. Levels IgA, lgG and CD4/CD8 of the two groups after treatment were higher than those before treatment （all P〈0.05）, and the IgA, IgG and CD4/CD8 of observation group [（1.84±0.91）g/L, （14.75±0.87） g/L, （1.76±0.72）] was higher than the control group [（1.29±0.63）g/L, （10.27±0.94） g/L, （1.33±0.45）] （all P〈0.05）. The observation group was better than the control group in the aspects of dehydration correction, fever, abdominal pain disappearance and stool recovery, and the differences were statistically significant （all P〈0.05）.Conclusion Jinshuangqi tablets combined with Smecta in treating pediatric diarrhea can enhance the immune function of children, improve the symptoms, and improve clinical curative effect.
出处
《社区医学杂志》
2017年第23期14-16,共3页
Journal Of Community Medicine
