摘要
目的探讨泛素化特异性蛋白酶22(USP22)在甲状腺乳头状癌、甲状腺腺瘤和结节性甲状腺肿中的表达情况,分析其与临床病理参数的关系。方法应用免疫组织化学方法检测惠州市中心人民医院2010-2015年收治的10例结节性甲状腺肿、20例甲状腺腺瘤和60例甲状腺乳头状癌组织中USP22蛋白的表达,分析其与性别、年龄、肿物大小、多灶性、包膜浸润和Ⅵ区淋巴结转移等临床病理特征的关系。结果 USP22在甲状腺乳头状癌组织中的表达高于甲状腺腺瘤组织及结节性甲状腺肿组织,差异有统计学意义(P<0.05);USP22的表达与Ⅵ区淋巴结转移和肿瘤大小有关(P<0.05),而与性别、年龄、多灶性、包膜浸润等特征无关(P>0.05)。结论与结节性甲状腺肿和甲状腺腺瘤相比,USP22在甲状腺乳头状癌组织细胞中高表达,其高表达与肿瘤大小和Ⅵ区淋巴结转移有关。USP22蛋白可能是一种新的预测甲状腺乳头状癌预后的肿瘤标记物以及生物治疗靶点。
Objective To investigate the expression of ubiquitin specific protease 22（USP22） in human thyroid papillary carcinoma, thyroid adenoma and nodular goiter, and to analyze its relationship with the clinical pathologic characteristics（gender, age, tumor size, multifocal, central lymph node metastasis）. Methods The expression of USP22 protein was detected by immunohistochemistry in 10 cases of nodular goiter, 20 cases of thyroid adenoma and 60 cases of thyroid papillay carcinoma in Huizhou Municipal Central Hospital from 2010 to 2015. The clinical pathologic factors（gender, age, tumor size,multifocality, extracapsular invasion and central lymph node metastasis） were collected, and the correlation between the expression of USP22 protein and various clinicopathologic factors were analyzed. Results The expression level of USP22 protein in thyroid papillary carcinoma tissues was significantly higher than that in thyroid adenoma or nodular goiter（P〈0.05）.The expression of USP22 protein had close correlation with tumor size and central lymph node metastasis（P〈0.05）, and had no association with gender, age, multifocality and extracapsular invasion（P〈0.05）. Conclusion Compared with nodular goiter and thyroid adenoma, the expression level of USP22 in thyroid papillary carcinoma is significantly higher, and the expression of USP22 protein has close correlation with tumor size and central lymph node metastasis in thyroid papillary carcinoma, which shows that USP22 may be involved in the occurrence and development of thyroid papillary carcinoma,and may be served as a new tumor marker and therapeutic target of thyroid carcinoma.
出处
《海南医学》
CAS
2017年第23期3836-3839,共4页
Hainan Medical Journal
关键词
甲状腺乳头状癌
泛素化特异性蛋白酶22
Ⅵ区淋巴结转移
免疫组织化学
Thyroid papillary carcinoma
Ubiquitin specific protease 22 （USP22）
Central lymph node metasta-sis
Immunohistochemistry
