摘要
为提高卡维地洛溶解度和溶出速率,采用固体分散技术,通过溶剂法,以PVP K30为载体,以药辅质量比(CAR∶PVP K30)、溶剂用量、溶剂蒸发的温度为考察因素,采用正交试验法,得出卡维地洛固体分散体制备的最佳工艺:药物与载体材料质量比1∶9,加入10 m L无水乙醇,蒸发溶剂的温度50℃。与卡维地洛原料药相比,按最佳工艺制备的卡维地洛固体分散体,60min溶出百分率从16.25%提高到98.04%。
In order to improve the solubility and dissolution rate of carvedilol,the solid dispersion technology is used,through the solvent method,and PVP K30 is used as the carrier,the drug assisted mass ratio（CAR∶ PVP K30）,the amount of solvent and the temperature of solvent evaporation are selected as tested factors,orthogonal test method is used to obtain the optimum process for the preparation of carvedilol solid dispersion system： The mass ratio of drug and carrier material is 1∶ 9,adding 10 m L anhydrous ethanol,and the temperature of evaporation solvent is 50 ℃. Compared with the carvedilol API,the solid dispersion of carvedilol prepared by the best process has a 29-fold increase in solubility,and the percentage of dissolution after 60 min increases from below 16. 25% to 98. 04%.
出处
《盐城工学院学报（自然科学版）》
CAS
2017年第4期63-67,共5页
Journal of Yancheng Institute of Technology:Natural Science Edition
