摘要
目的考察人参皂苷Rg3羟丙基-β-环糊精包合物的制备工艺及其表征。方法比较研磨法和水溶液搅拌法制备人参皂苷Rg3羟丙基-β-环糊精包合物,以包合率为指标,采用L9(34)正交试验设计优化包合工艺条件,采用薄层色谱法、DSC差热分析、红外光谱法、X-射线衍射法等分析手段对包合物进行表征,测定包合物的体外溶出度。结果选择水溶液搅拌法制备包合物,最佳包合工艺为人参皂苷Rg3与羟丙基-β-环糊精的质量比1∶100,搅拌时间2 h,温度25℃,其包合率为86.11%,通过表征说明包合物已经形成,包合物的溶出速率明显提高。结论人参皂苷Rg3羟丙基-β-环糊精包合物制备工艺稳定可行,溶解性显著提高。
Objective To prepare ginsenoside Rg3 and hydroxypropyl-β-cyclodextrin inclusion complex and to investigate its physical properties. Methods The inclusion complex was prepared by the grinding and aqueous solution-stirring method respectively. Effects of the inclusion conditions were optimized by L9 （ 34 ） orthogonal test with inclusion rate as index, and the inclusion complex was identified by TLC, DSC, IR and XRD. The dissolution of inclusion complex in vitro was determinated. Results The inclusion complex prepared by the aqueous solution-stirring method had higher inclusion rate. The best inclusion were as followings ：ratio of ginsenoside Rg3 and hydroxypropyl-/3-cyclodextrin was 1 ： 100, inclusion time was 2 h, inclusion temperature was 25 ℃. Under these conditions, inclusion rate of ginsenoside Rg3 was 86. 11%. All of the characterization methods showed that the inclusion complex had been formed. The dissolution rate of inclusion complex was significantly increased. Conclusions The inclusion technique is stable and feasible, and the solubility of inclusion complex increased obviously.
出处
《沈阳药科大学学报》
CSCD
北大核心
2017年第12期1033-1037,共5页
Journal of Shenyang Pharmaceutical University
基金
辽宁省自然科学基金项目(2013020159)
