摘要
目的:探讨拓扑异构酶Ⅱ(TopoⅡ)与人类表皮生长因子受体2(Her-2)对乳腺肿瘤术后转移复发预测价值。方法:选择2009-05-2012-05我院行手术治疗的200例乳腺肿瘤患者作为研究对象,收集乳腺肿瘤组织及癌旁组织,采用免疫组织化学染色检测Her-2、TopoⅡ表达;以患者转移复发作为观察指标,分析Her-2、TopoⅡ表达与乳腺肿瘤术后复发转移的关系。结果:乳腺肿瘤组织Her-2、TopoⅡ阳性表达率显著高于癌旁组织(P<0.05),术后复发转移组(83例)Her-2、TopoⅡ阳性表达率显著高于未复发转移组(117例)(P<0.05)。单因素分析显示,Ⅲ期患者转移复发率(66.7%或54/81)显著高于Ⅰ~Ⅱ期(22.4%或29/119)患者,Her-2表达阳性转移复发率显著高于Her-2表达阴性患者,TopoⅡ表达阳性转移复发率显著高于TopoⅡ表达阴性患者,各组间比较差异具有统计学意义(P<0.05)。多因素分析显示,临床分期、Her-2、TopoⅡ表达是影响乳腺肿瘤术后转移复发的独立危险因素(均P<0.05)。结论:乳腺肿瘤术后转移复发患者Her-2、TopoⅡ表达显著升高,Her-2、TopoⅡ均可以作为乳腺肿瘤术后转移复发的预测指标。
Objective：To explore the predicting value of Her-2 and TopoⅡ on breast cancer after surgery.Method：A total of 200 cases of breast cancer patients from May 2009 to May 2012 were selected,the breast cancer tissue and adjacent tissue were colected,and the expression of Her-2 and TopoⅡin tissues were detected by immunohistochemical staining.Recurrence and metastasis as observation index,the relationship between Her-2 and TopoⅡ and recurrence and metastasis of breast cancer after surgery was analyzed.Result：The positive expression rate of Her-2 and TopoⅡin cancer tissues were significantly higher than those in adjacent tissues（P〈0.05）,and the positive expression rate of Her-2 and TopoⅡin the recurrence and metastasis group were significantly higher than those in the non recurrence group（P〈0.05）Univariate analysis showed that the metastasis and recurrence rate of stageⅠ-Ⅱpatients was significantly higher than that in stageⅢ patients,the metastasis and recurrence rate of patients with Her-2 positive expression was significantly higher than that in patients with Her-2 negative expression.The metastasis and recurrence rate of patients with TopoⅡpositive expression was significantly higher than that in patients with the TopoⅡ negative expression,and the differences between the groups were statistically significant（P〈0.05）.Multivariate analysis showed that clinical stage,Her-2 and TopoⅡ expression were independent risk factors for metastasis and recurrence of breast cancer patients after surgery（all P〈0.05）.Conclusion：The Her-2 and TopoⅡexpression of breast cancer patients after surgery with recurrence and metastasis were significantly increased,so Her-2 and TopoⅡ could be used as predictors index for recurrence and metastasis of breast cancer after surgery.
出处
《临床血液学杂志（输血与检验）》
CAS
2017年第6期929-933,共5页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
拓扑异构酶Ⅱ
人类表皮生长因子受体2
乳腺肿瘤
手术治疗
转移复发
topoisomerase
human epidermal growth factor recepter-2
breast cancer
surgical treatment
metastasis and recurrence
