摘要
目的通过检测BIM基因多态性,探讨其与晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)铂类药物治疗疗效的关系。方法根据纳入及排除标准,选择2013年7月至2016年7月就诊于重庆市中医院肿瘤科的100例晚期NSCLC患者,所有患者均接受铂类药物治疗,采用多聚酶链反应方法检测患者外周血中BIM基因多态性,并定期随访获得临床资料,采用SPSS 13.0统计软件分析统计结果。结果在客观缓解率上,BIM基因无缺失多态性患者优于BIM基因缺失多态性的患者(ORR:48.8%vs.11.1%,χ~2=8.598,P=0.003),差异有统计学意义;而疾病控制率(78.0%vs.61.1%,χ~2=2.258,P=0.133)差异无统计学意义。Cox比例风险回归模型分析发现仅BIM基因多态性对无进展生存期(progressing-free survival,PFS)的影响有统计学意义(P=0.003),BIM基因无多态性的患者中位PFS长于BIM基因缺失多态性的患者(14.0个月vs.10.0个月,P=0.001),差异有统计学意义;BIM基因型多态性与不良反应的关系差异无统计学意义(χ~2=1.62,P>0.1)。结论BIM基因缺失多态性为影响晚期NSCLC铂类药物治疗PFS的独立预后因素,检测患者BIM基因多态性对晚期NSCLC铂类药物治疗疗效的预后评估有重要意义。
Objective To explore the relationship between BIM gene polymorphism and therapeutic efficacy in the advanced non-small cell lung cancer( NSCLC) with platinum drugs. Methods It was collected that 100 patients who were diagnosed with advanced NSCLC and received therapy with platinum drugs in oncology department of Chongqing Traditional Chinese Medicine Hospital from July 2012 to July 2015. The peripheral blood of patients was collected and genotype of BIM gene polymorphism was detected by polymerase chain reaction( PCR). Statistical analysis was performed by SPSS version 13. 0. Results On the objective response rate( ORR),BIM gene with no polymorphism type was significantly better trend than polymorphism types in ORR( 48.8% vs. 11. 1%,χ~2= 8. 598,P = 0. 003). The BIM gene polymorphism was the independent prognostic factors for progressin-free survival( PFS) by univariate Cox analysis. The median PFS in BIM gene with no polymorphism type were significantly longer than with polymorphism type( 14.0 months vs. 10.0 months,P = 0.001). However,BIM gene polymorphism did not have significant influence on adverse drug reaction( χ~2=1.62,P>0. 1). Conclusions The BIM gene polymorphism is the independent prognostic factor for PFS in patients of NSCLC, and detection of BIM gene polymorphism is important for prognostic evaluation of therapeutic efficacy in the advanced NSCLC with platinum drugs.
出处
《中华肺部疾病杂志（电子版）》
CAS
2017年第6期698-703,共6页
Chinese Journal of Lung Diseases(Electronic Edition)
基金
重庆市卫生计生委医学科研课题(20143007)
