摘要
目的对比分析婴幼儿呼吸道合胞病毒(RSV)感染毛细支气管炎与非RSV感染毛细支气管炎的临床特征。方法选择2016年4月至2017年4月湖南省儿童医院收治的90例毛细支气管炎患儿作为研究对象,根据患儿的病毒病原学检查结果分为RSV组(58例)和非RSV组(32例),比较两组的一般资料、临床症状及实验室检测结果。结果(1)一般资料:两组患儿的性别、出生体质量、病程比较差异均无统计学意义(均P>0.05);RSV组患儿年龄、入院体质量明显小于非RSV组[年龄(月):3.36±1.29比6.83±1.57,入院体质量(kg):7.21±1.84比8.97±2.23,均P<0.05],住院时间明显大于非RSV组(d:8.36±0.72比6.81±0.94,P<0.05)。(2)临床症状:RSV组发绀患儿数明显多于非RSV组(10例比0例,P<0.05),发热、胃肠症状、喘息、气促、哮鸣音等临床症状比较差异均无统计学意义(均P>0.05);(3)实验室检测:RSV组中性粒细胞比例(NEU)、白细胞计数(WBC)、C-反应蛋白(CRP)明显低于非RSV组[NEU:0.22±0.11比0.36±0.15,WBC(×109/L):6.84±2.19比9.35±2.33,CRP(mg/L):3.25±1.08比7.87±1.62,均P<0.05];淋巴细胞比例(LYM)、血小板计数(PLT)、丙氨酸转氨酶(ALT)明显高于非RSV组[LYM:0.67±0.18比0.55±0.16,PLT(×109/L):453.45±22.83比371.22±20.64,ALT(U/L):30.73±4.19比22.46±3.57,均P<0.05];两组CK-MB比较差异无统计学意义(U/L:28.16±3.51比23.07±2.96,P>0.05)。结论 RSV感染毛细支气管炎患儿的年龄明显小于非RSV感染毛细支气管炎患儿,且其临床症状更为严重,甚至可能出现肝功能损害,应当引起医护人员的高度重视,并给予相应的治疗措施。
Objective To compare the clinical features between respiratory syncytial virus（RSV） origin and non-RSV origin in infants with bronchiolitis.Methods 90 children with bronchiolitis who admitted to Children＇s Hospital of Hunan Province from April 2016 to April 2017 were selected as study subjects,and were divided into two groups（RSV group,n = 58 vs.non-RSV group,n = 32） in accordance with the results of viral etiological examination.The baseline data,symptoms,and laboratory test results in children from each group were compared.Results（1） The baseline data：there was no significant difference in gender,course of disease and birth weight between the two groups（all P 〉0.05）.The age in RSV group was significantly younger and admission weight was significantly lower than those in non-RSV group [age（month）：3.36±1.29 vs.6.83±1.57,body mass in admission（kg）：7.21±1.84 vs.8.97±2.23,both P 〈0.05],and hospital stay was significantly longer than those in non-RSV group（d：8.36±0.72 vs.6.81±0.94,P 〈0.05）.（2） Clinical symptoms：more children in RSV group suffered from cyanosis than those in non-RSV group（10 cases vs.0 case,P〈 0.05）,however,other symptoms such as fever,gastrointestinal symptoms,tachypnea,dyspnea,and wheeze etc,were no difference between this two groups（all P〉 0.05）.（3） The laboratory tests：the percentage of Neutrophils（NEU）,the count of while blood cell（WBC）,and the measure of C-reactive protein（CRP） in RSV group were significantly lower than those in non-RSV group [NEU：0.22 ±0.11 vs.0.36±0.15,WBC（×10^9/L）：6.84±2.19 vs.9.35±2.33,CRP（mg/L）：3.25±1.08 vs.7.87±1.62,all〈 P〈0.05],and the percentage of lymphocyte（LYM）,platelet count（PLT） and alanine aminotransferase（ALT） were higher than those in non-RSV group [LYM：0.67±0.18 vs.0.55±0.16,PLT（×10^9/L）：453.45±22.83 vs.371.22±20.64,ALT（U/L）：30.73±4.19 vs.22.46±3.57,all P 〈0.05].Nevertheless,no significant difference was found in the v
出处
《实用检验医师杂志》
2017年第4期230-233,共4页
Chinese Journal of Clinical Pathologist
