摘要
目的:评价红景天苷对糖尿病心肌病(DCM)大鼠的疗效。方法:采用高脂饮食联合腹腔注射链脲佐菌素方法诱导雄性糖尿病大鼠,继续高脂高糖饮食,筛选糖尿病心肌病模型大鼠。将造模成功大鼠随机分为DCM组,红景天苷低、中、高剂量组及卡托普利组,另设正常对照组给予常规饲料,按组别不同分别给予药物干预,8周后采血检测各组空腹血糖、胰岛素、糖化血红蛋白、B型钠尿肽(BNP)及血管紧张素-Ⅱ(Ang-Ⅱ)水平;超声心动图评价各组大鼠心的结构和功能,观察各组大鼠心肌组织病理变化。结果:与DCM组比较,红景天苷各剂量组大鼠空腹血糖及糖化血红蛋白水平显著降低。与DCM组比较,红景天苷各剂量组大鼠BNP、Ang-Ⅱ水平显著下降,且与药物浓度呈正相关。与DCM组比较,红景天苷各剂量组大鼠左室舒张末压、左室收缩末期内径及左室舒张末期内径下降,射血分数显著升高。与DCM组比较,红景天苷各剂量组大鼠心肌组织结构紊乱程度减轻。结论:红景天苷可以改善糖尿病心肌病大鼠的心功能。
Objective： To evaluate the effect of salidroside on experimental rats with diabetic cardiomyopathy （DCM）. Methods： Male diabetic rats were induced by intraperitoneal injection of streptozotocin. The rats were then fed with high-fat and high-sugar diet so as to select the DCM rat model. The modeled rats were randomly divided into DCM group, salidroside low-dose group, salidroside middle-dose group, high-dose salidroside group and captopril group, and another rats in the normal control group were given conventional food. After 8 weeks, the fasting blood glucose, insulin, glycosylated hemoglobin, B type natriuretic peptide （BNP） and angiotensin Ⅱ （Ang-Ⅱ） levels were detected in each group. Echocardiography was used to evaluate the cardiac structure and function, and the pathological changes of myocardial tissue were observed. Results： Compared with the model group, the levels of BNP and Ang-Ⅱ changed significantly in the salidroside drug intervention groups, and it was related to drug dosage. The degree of heart function damage decreased in the salidroside drug intervention groups. Conclusion： Salidroside may improve cardiac function in rats with diabetic cardiomyopathy.
出处
《解剖学杂志》
CSCD
北大核心
2017年第6期685-688,共4页
Chinese Journal of Anatomy
基金
河北省卫生厅项目(20130062)
