摘要
目的 探讨卡介苗（BCG）、羟喜树碱（HCPT）及吡柔比星（THP）三联膀胱灌注化疗方案对行经尿道膀胱镜下肿瘤电切术（TURBT）浅表型膀胱癌患者复发风险、生存时间及实验室指标的影响.方法 研究对象选取本院2011年1月至2013年8月收治行TURBT术浅表型膀胱癌患者共130例,采用随机区组法分为对照组（65例）和观察组（65例）,分别给予HCPT＋THP和BCG＋HCPT＋ THP膀胱灌注化疗;比较两组患者随访复发率、远期生存率、治疗前后肿瘤标志物指标水平、血管内皮生长因子（VEGF）水平及不良反应发生率等.结果 观察组患者随访复发率显著低于对照组（P＜0.05）;观察组患者远期生存率显著高于对照组（P＜0.05）;观察组患者治疗后肿瘤标志物指标和VEGF水平均显著低于对照组、治疗前（P＜0.05）;同时两组患者不良反应发生率比较差异无统计学意义（P＞0.05）.结论 三联膀胱灌注化疗方案用于行TURBT术浅表型膀胱癌患者可有效降低复发风险,延长生存时间,下调肿瘤标志物和VEGF水平,且未增加不良反应发生风险.
Objective To investigate the effect of triple chemotherapy including bacillus calmette guerin （BCG） and hydroxycamptothecin （HCPT） and pirarubicin （THP） with bladder perfusion on recurrence risk,survival time and laboratory parameters of patients with superficial bladder cancer after （transurethral resection of bladder cancer,TURBT）.Methods A total of 130 patients with superficial bladder cancer after TURBT were chosen from January 2011 to August 2013 in our hospital and randomly divided into two groups,control group with HCPT ＋ THP and observation group with BCG ＋ HCPT ＋ THP,65 cases each group.and the recurrence rate with follow-up,the long-term survival rate,the levels of tumor marker and vascular endothelial growth factor （VEGF） and adverse reaction incidence of both groups were compared between two groups.Results The recurrence rate with follow-up of observation group was significantly lower than control group（P 〈0.05）.The long -term survival rate of observation group was significantly higher than control group （P 〈 0.05）.The levels of tumor marker and VEGF after treatment of observation group were significantly lower than control group and before treatment （P 〈 0.05）.There was no significant difference in the adverse reactions incidence between two groups（P 〉 0.05）.Conclusions Triple chemotherapy with bladder perfusion on recurrence risk,survival time and laboratory parameters of patients with superficial bladder cancer after TURBT can efficiently reduce the recurrence risk,prolong the survival time,down-regulate the levels of tumor markers and VEGF and not increase the risk of adverse reactions.
出处
《国际泌尿系统杂志》
2017年第6期834-837,共4页
International Journal of Urology and Nephrology
关键词
膀胱肿瘤
肿瘤复发
局部
卡介苗
喜树碱
Urinary Bladder Neoplasms
Neoplasm Recurrence,Local
BCG Vaccine
Camptothecin
