摘要
在人类疾病史中,寄生虫病由来已久,且一直是无法根除的重大公共卫生问题。氯喹、吡喹酮、阿苯达唑、甲苯达唑等药物虽杀虫效果较为理想,却存在产生耐药性和毒副作用较大等诸多弊端,而植物来源的药物具有毒副作用小、疗效好等优点,弥补了上述药物的不足。本文就一些常见的人体寄生虫病的植物或植物提取物治疗展开综述,介绍了一些植物药物治疗常见寄生虫病的机制和疗效,为临床上使用植物来源的药物治疗寄生虫病提供参考依据。
In the history of human disease, parasitic disease has been existed for a long time, and is a major public health problem that has been unable to eradicate. Although anti-parasite drugs such as chloroquine, praziquantel, albendazole and mebendazole, have ideal effects on killing some parasites, they also have disadvantages like drug resistance and quite strong side-effects. However, plant-derived drugs have advantages like small side-effects and high curative rates. This review summarizes anti-parasite mechanisms and curative effects of plant-derived drugs, which will contribute to the development of novel plant-derived drugs against parasitic diseases.
作者
陈静波
吕志跃
CHEN Jing-bo;LU Zhi-yue(Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080;Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080;Ministry of Education Key Laboratory of Control of Tropical Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510080;Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, Guangdong 510080, China)
出处
《热带医学杂志》
CAS
2017年第12期1684-1689,共6页
Journal of Tropical Medicine
基金
国家重点研发计划项目(2016YFC1202003,2016YFC12005000)
国家自然科学基金(81371836,81572023,81271855,81261160324)
中国科技部国家科学技术资源基础平台项目(TDRC-2017-22)
广东省自然科学基金(2014A030313134)
广东省科技计划项目(2016A050502008)
广州市科技计划项目(201607010029)
中央高校基本科研业务费专项资金资助(17ykpy11)
中山大学2016年教学改革与课程建设重点课题
国家大学生创新训练项目
广东省大学生创新训练项目
中山大学本科生学生业余科研暨科研助理计划项目
关键词
寄生虫病
植物来源药物
治疗
Parasitic disease
Plant-derived drug
Treatment
