摘要
目的:了解厦门市仙岳医院(以下简称"我院")住院患者苯海索使用情况,为临床合理用药提供参考。方法:采用一日法,对2015年10月21日我院全部住院患者抗精神病药和苯海索的使用情况进行调查与分析。结果:共806例患者使用抗精神病药,其中联合应用苯海索者299例(占37.10%);苯海索的平均日剂量为(3.62±0.90)mg;与苯海索联合应用率较高的抗精神病药包括氟哌啶醇、氨磺必利和氯丙嗪;老年患者(≥60岁)苯海索使用率明显低于非老年患者(<60岁),差异有统计学意义(P<0.000 1);男性患者苯海索使用率及其平均日剂量高于女性,但差异均无统计学意义(P>0.05)。结论:我院住院患者苯海索使用率较高,其合理性还需进一步探讨,以保证临床合理用药。
OBJECTIVE： To investigate the application status of trihexyphenidyl in inpatients in Xiamen Xianyue Hospital（ hereinafter referred to as ＂our hospital＂）,so as to provide reference for the rational application of drugs in clinic. METHODS： One-day time point method was adopted,investigation and analysis was conducted on application status of antipsychotics and trihexyphenidyl in inpatients on Oct. 21 st,2015. RESULTS： There were 806 patients received antipsychotics,among which 299 patients（ 37. 10%） received antipsychotics combined with trihexyphenidyl;the average daily dosage of trihexyphenidyl was（ 3. 62 ± 0. 90） mg. The top three drugs with high drug combination rate with trihexyphenidyl were respectively haloperidol,amisulpride and chlorpromazine. The application rate of trihexyphenidyl in geriatric group（ ≥60 years old） was lower than that of non-geriatric group（ 60 years old）,with statistically significant difference（ P〈0. 000 1）. The application rate and average daily dosage of trihexyphenidyl in males were higher than those of females,without any statistical significance（ P〈0. 05）. CONCLUSIONS： The application rate of trihexyphenidyl in inpatients of our hospital is relatively high,yet the rationality still need the further research,so as to ensure the rational application of drugs in clinic.
出处
《中国医院用药评价与分析》
2017年第11期1540-1542,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
抗精神病药
苯海索
合理用药
锥体外系反应
Antipsychotics
Trihexyphenidyl
Rational drug application
Extrapyramidal side reactions
