摘要
目的探讨药师干预对痰热清注射液合理应用的影响。方法选取我院2015年1月—2016年1月住院并使用痰热清注射液的428例,按照随机数字表法分为对照组和干预组,每组各214例,两组均予痰热清注射液、止咳祛痰、解痉平喘、清热解毒等治疗,干预组在应用痰热清注射液时予药师干预。观察两组痰热清注射液不合理使用情况、药物不良反应(ADR)发生率、住院总费用、住院天数、痰热清注射液总费用及所占住院总费用百分比。结果两组与氯化钾等药物配伍使用、未使用规定溶媒剂量、超适应证用药、超剂量用药发生率比较差异均有统计学意义(P<0.05)。干预组、对照组ADR发生率分别为1.87%、9.81%,差异有统计学意义(P<0.05)。与对照组比较,干预组住院总费用、住院天数、痰热清注射液总费用及占住院总费用百分比明显减少,差异均有统计学意义(P<0.05)。结论药师干预痰热清注射液的合理使用可有效减少ADR发生率、住院天数、住院费用等,保证临床合理用药。
Objective To investigate effect of pharmacists intervention on rational use of Tanreqing injections. Meth-ods A total of 428 inpatients using Tanreqing injections during January 2015 and January 2016 were divided into interven-tional group （n=214） and control group （n=214） according to random number table method. All inpatients received treat-ments such as Tanreqing injections, relieving cough, expelling phlegm, spasmolysis and antiasthma, clearing away the heat e-vil and expelling superficial evils, and pharmacists interfered during using Tanreqing injections in intervention group. Unrea-sonable usage conditions of Tanreqing injections, incidence rate of adverse drug reactions （ ADR） , total hospitalization expen-ses, hospitalization days and proportion of total cost for Tanreqing injections to total hospitalization expenses were analyzed in two groups. Results There were significantly differences in compatibility of drugs with Potassium Chloride and so on, no use of regular solvent dosage, over indications of drug usage and incidence rate of overdosage use in two groups （P〈0. 05）. ADR incidence rates were 1. 87% in interventional group and 9. 81% in control group, and the difference was statistically signifi-cant between the two groups （P〈0. 05）. Compared with those in control group, values of total hospitalization expenses, hos-pitalization days and proportion of total cost for Tanreqing injections to total hospitalization expenses were significantly de-creased in interventional group （P〈0. 05）. Conclusion Pharmacists intervention in rational use of Tanreqing injections may decrease ADR incidence rate, hospitalization days and hospitalization expenses and ensure rational use of drugs.
作者
李昌
常冰
王广伟
杨龙飞
郑霄
赵铁梅
LI Chang;CHANG Bing;WANG Guang-wei;YANG Long-fei;ZHENG Xiao;ZHAO Tie-mei(Department ofPharmacy;the Third Department of Cardiology,1. Traditional Chinese Medicine Hospital of Shijiazhuang,Shijiazhuang050051,China;Deparment of Cadre Ward,Bethune International Peace Hospital of PLA,Shijiazhuang 050084,China)
出处
《临床误诊误治》
2017年第12期98-101,共4页
Clinical Misdiagnosis & Mistherapy
基金
河北省中医药管理局科研计划项目(2015037)
