摘要
藻蓝蛋白是一种存在于蓝藻、螺旋藻细胞中的色素蛋白复合体,除了能够捕获光能为藻类细胞提供能量外,藻蓝蛋白还具有抗炎性、抗肿瘤、抗氧化等多种生理功能,全面了解和掌握藻蓝蛋白的生理调控功能以及作用机制对藻蓝蛋白的开发与利用有着重要的指导意义。作者以藻蓝蛋白的研究现状出发,分别从抗肿瘤、抗炎、抗氧化以及免疫调节活性几个方面对藻蓝蛋白的生理功能和作用机制进行了阐述,对藻蓝蛋白提取过程中关键瓶颈——藻毒素的去除方法进行了总结和分析,并进一步提出了研究藻蓝蛋白调控机制的新筛选方法。作者为深入研究藻蓝蛋白的调控机理以及进一步开发安全性药物提供参考。
Phycocyanin is a kind of light-harvesting compound existed in Spirulina. In addition to providing energy for the survival of algae cells by capturing light’ phycocyanin possesses many physiological functions such as anti-tumor ’ anti-inflammatory and antioxidant. Fully understanding the physiological function and regulation mechanism of phycocyanin has important guiding significance to its development and utilization. This paper reviews the anti-tumor, anti-inflammatory, antioxidant and immunoregulatory activity functions of phycocyanin, analyzes the removal method of the key bottlenecks in the process of phycocyanin extraction-microcystin, and also puts forward a novel method of studying phycocyanin regulation mechanism. This present paper provides references for further investigation into regulation mechanisms of phycocyanin and development of safety drugs.
作者
郝帅
秦玉
王成涛
HAO Shuai;QIN Yu;WANG Chengtao(Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Technology ＆ Business University ,Beijing 100048 , China;Beijing Engineering and Technology Research Center of Food Additives , Beijing Technology ＆ Business University , Beijing 100048 , China)
出处
《食品与生物技术学报》
CAS
CSCD
北大核心
2017年第12期1233-1240,共8页
Journal of Food Science and Biotechnology
基金
国家自然科学基金项目(31701575
31571801)
北京市科技计划项目(Z171100002217019)
北京市优秀人才培养资助青年骨干个人项目(2016000020124G025)
北京工商大学青年教师科研启动基金项目(QNJJ2016-31)
关键词
藻蓝蛋白
功能性食品
生理活性
phycocyanin,functional food,physiological activity
