摘要
目的:探讨变应性鼻炎患者血清中YKL-40含量与嗜酸性粒细胞功能、Th1/Th2型及Treg/Th17型免疫的相关性。方法:选择本院收治的变应性鼻炎患者310例作为变应性鼻炎组,同期在本院进行体检的健康志愿者100例作为正常对照组。对比两组研究对象血清中YKL-40含量、嗜酸性粒细胞功能、Th1/Th2及Treg/Th17细胞因子含量的差异。采用Pearson检验评估变应性鼻炎患者血清YKL-40含量与病情严重程度的相关性。结果:变应性鼻炎组血清中YKL-40的含量高于正常对照组;变应性鼻炎组血清中嗜酸性粒细胞功能IgE、Eotaxin-2的含量高于正常对照组;血清中Th1细胞因子IFN-γ、IL-12的含量低于正常对照组,Th2细胞因子IL-4、IL-13的含量高于正常对照组;血清中Treg细胞因子TGF-β的含量低于正常对照组,Th17细胞因子IL-17的含量高于正常对照组高。经Pearson检验发现,变应性鼻炎患者血清中YKL-40的含量与嗜酸性粒细胞功能、Th1/Th2型及Treg/Th17型免疫状态直接相关。结论:变应性鼻炎患者存在血清YKL-40含量异常高表达,且具体表达量与病情严重程度呈正相关。
Objective：To discuss the correlation of serum YKL-40 content with eosinophil function as well as Th1/Th2 and Treg/Th17 immunity in patients with allergic rhinitis.Methods：310 patients with allergic rhinitis who were treated in the hospital between January 2015 and May 2017 were selected as allergic rhinitis group and 100 healthy volunteers who received physical examination in the hospital during the same period were selected as normal control group.The differences in serum YKL-40 content,eosinophil function as well as Th1/Th2 and Treg/Th17 cytokine contents were compared between the two groups.Pearson test was used to assess the correlation between serum YKL-40 content and disease severity in patients with allergic rhinitis.Results：Serum YKL-40 content of allergic rhinitis group was higher than that of normal control group;serum eosinophil function IgE and Eotaxin-2 contents of allergic rhinitis group were higher than those of normal control group;serum Th1 cytokines IFN-γand IL-12 contents were lower than those of normal control group while Th2 cytokines IL-4 and IL-13 contents were higher than those of normal control group;serum Treg cytokine TGF-βcontent was lower than that of normal control group while Th17 cytokine IL-17 content was higher than that of normal control group.Pearson test showed that serum YKL-40 content in patients with allergic rhinitis was directly correlated with the eosinophil function as well as Th1/Th2 and Treg/Th17 immunity.Conclusion：Serum YKL-40 content is abnormally high in patients with allergic rhinitis,and the specific expression is positively correlated with the disease severity.
出处
《海南医学院学报》
CAS
2017年第20期2873-2876,共4页
Journal of Hainan Medical University
基金
国家自然科学基金(81460094)~~
