摘要
目的:探讨微创前外侧入路下不同髋关节置换方式对股骨颈骨折患者骨代谢、关节疼痛的影响。方法:收集在本院进行手术治疗的股骨颈骨折患者110例,随机分为对照组及观察组各55例。对照组接受微创前外侧入路下半髋置换术、观察组接受微创前外侧入路下全髋置换术。对比两组手术前后骨代谢、关节疼痛相关指标含量的差异。结果:术前,两组血清中骨形成指标、骨吸收指标、炎症指标、疼痛介质含量的差异无统计学意义。术后1月,观察组血清中骨形成指标PINP、BAP、BGP的含量高于对照组;血清中骨吸收指标β-CTX、TRACP-5b的含量低于对照组;血清中炎症指标IL-1、TNF-α的含量低于对照组;血清中疼痛介质5-HT、PGE2的含量低于对照组。结论:微创前外侧入路下全髋置换术,可更为有效的促进骨形成/骨吸收平衡形成,减轻关节疼痛。
Objective：To explore the effect of different hip replacement methods under minimally invasive anterolateral approach on bone metabolism and joint pain in patients with femoral neck fracture.Methods：A total of 110 patients with femoral neck fracture who were treated in Ruijin Hospital North,Shanghai Jiaotong University School of Medicine between July 2015 and January 2017 were collected and divided into control group and observation group by random number table,each with 55 cases.Control group accepted half hip replacement under minimally invasive anterolateral approach,and observation group accepted total hip replacement under minimally invasive anterolateral approach.The differences in contents of bone metabolism and joint pain-related indexes were compared between the two groups before and after surgery.Results：Before surgery,serum contents of bone formation indexes,bone resorption indexes,inflammatory indexes and pain mediators were not statistically significant between the two groups.1 month after surgery,serum bone formation indexes PINP,BAP and BGP contents of observation group were higher than those of control group;serum bone resorption indexes β-CTX and TRACP-5 bcontents were lower than those of control group;serum inflammatory indexes IL-1 and TNF-αcontents were lower than those of control group;serum pain mediators 5-HT and PGE2 contents were lower than those of control group.Conclusion：Total hip replacement under minimally invasive anterolateral approach is more effective to promote the formation of bone formation/bone resorption balance and reduce the joint pain.
出处
《海南医学院学报》
CAS
2017年第20期2791-2793,2797,共4页
Journal of Hainan Medical University
基金
上海市卫生局计划项目(20131028)~~
关键词
股骨颈骨折
髋关节置换
骨代谢
关节疼痛
Femoral neck fracture
Hip replacement
Bone metabolism
Joint pain
