摘要
目的:探讨中药熏蒸疗法对尺桡骨骨折延迟愈合患者血液流变学及血清可溶性血管细胞黏附因子-1(s VCAM-1)、骨钙素(BGP)及人胰岛素生长因子-1(IGF-1)水平的影响。方法:将我院收治的110例尺桡骨骨折延迟愈合患者随机分为观察组和对照组,每组55例。对照组患者行重新复位再固定治疗,观察组在对照组基础上行中药熏蒸治疗。比较两组患者的临床疗效,分析各时点患者肘关节和腕关节活动功能恢复情况、血液流变学以及血清s VCAM-1、BGP及IGF-1水平。结果:治疗后观察组治愈率和治疗总有效率均显著高于对照组(P<0.05)。第2、3疗程后观察组患者肘关节屈伸活动度、旋转活动度以及VAS评分均明显优于对照组(P<0.05);治疗第2疗程以后观察组患者腕关节背伸和掌屈活动度明显优于对照组(P<0.05);观察组患者各血液流变学指标较对照组均显著降低(P<0.05);治疗第1、2、3疗程结束后观察组患者血清s VCAM-1水平明显低于对照组,血清BGP、IGF-1水平显著高于对照组(P<0.05)。结论:中药熏蒸治疗尺桡骨骨折延迟愈合具有良好疗效,可明显改善血液流变学指标,降低血清s VCAM-1水平,提高血清BGP、IGF-1水平,利于骨折愈合和肘关节、腕关节功能恢复。
Objective： To investigate the effect of herbal fumigation on serum sVCAM-1, BGP, IGF-1 levels and hemorhe- ology of patients with delayed fracture healing of ulnoradial diaphyses. Method： A total of 110 patients with delayed fracture healing of ulnoradial diaphyses were randomly divided into observation group and control group. 55 patients in control group were treated by close reduction fixation and 55 patients in observation group were treated by herbal fumigation combined with close reduction fixation. The clinical efficacy was compared in two groups and the recovery of elbow and wrist, hemorheology and se- rum sVCAM-1, BGP, IGF-1 levels were detected and analyzed. Result： The curative rate and total effective rate of observation group were significantly higher than those of control group （P〈0.05）. The flexion mobility, rotary motion of elbow joint and VAS score of patients in obser- vation group were significantly better than those of control group after the second and third course （P〈0.05）. The flexion mobility of wrist in observation group was significantly better than those in control group after the second and third course （P〈0.05）. The hemorheology indexes of observation group were significantly lower than those of control group after the second and third course （P〈0.05）. The serum sVCAM-1 level was signifi-cantly reduced and serum BGP, IGF-1 levels were significantly increased in observation group compared with control group after the first, second and third course （P〈0.05）. Conclusion： Herbal fumigation has favorable efficacy to delayed fracture healing of ulnoradial diaphyses, which can improve indexes of hemorheology, reduce serum sVCAM-1 level, increase serum BGP, IGF-1 levels and promote the heal of ulnoradial fracture and recovery of elbow joint and wrist.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2017年第12期1370-1375,共6页
Chinese Journal of Rehabilitation Medicine
关键词
中药熏蒸
骨折延迟愈合
尺桡骨
血液流变学
肘关节
腕关节
herbal fumigation
delayed fracture healing
ulnoradial diaphyses
hemorheology
elbow
wrist
