摘要
内皮祖细胞(EPCs)是一类来源于成人骨髓及外周血中的干细胞,能定向增殖分化为内皮细胞,EPCs参与了出生后缺血组织的血管发生和血管损伤后的修复。现代研究发现,EPCs对心脑血管疾病、糖尿病及高血压等疾病中均具有治疗作用。EPCs的发现让人们对血管的生成有了新的认识,这为修复损伤血管内皮方面提供了潜在的治疗方法。本文总结了近年来EPCs的研究发现,就其在介导组织损伤修复方面做一综述。
Endothelial progenitor cells are a kind of stem cells （EPCs） derived from adult bone marrow and peripheral blood, Which can differentiate into endothelial cells. EPCs participate in angiogenesis of postnatal ischemic tissue and repair the injured vascular. Modem studies have found that EPCs have a therapeutic effects in cardiovascular and cerebrovascular diseases, diabetes, hypertension and so on. The discovery of EPCs gives a new insights into the generation of blood vessels and provides a potential treatment for repairing the vascular endothelial. This review summarizes the study of EPCs in recent years and makes a brief overview about tissue damage repair
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2017年第24期2633-2636,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81603405)
关键词
内皮祖细胞
动员
归巢
组织损伤
修复
endothelial progenitor cell
mobilization
homing
tissuedamage
repair
