摘要
目的:研究缺血性脑卒中患者血清HMGB1、sTLT-1含量与氧化应激反应、内皮损伤程度的相关性。方法:选择2015年2月-2017年3月期间在西安市周至县人民医院诊断为缺血性脑卒中的患者作为研究的卒中组,选择同期体检的健康者作为研究的对照组。采集血清并测定HMGB1、sTLT-1、氧化应激反应分子、内皮损伤分子的含量。结果:卒中组患者血清中HMGB1、sTLT-1、vWF、vWF-cp、sTM、ET-1、D-D、8-OHdG、LPO、NOS的含量显著高于对照组,T-SOD、GSH-Px的含量显著低于对照组;HMGB-1高含量的脑卒中患者血清中T-SOD、GSH-Px的含量显著低于HMGB-1低含量的脑卒中患者,8-OHdG、LPO、NOS的含量显著高于HMGB-1低含量的脑卒中患者;sTLT-1高含量的脑卒中患者血清中vWF、vWF-cp、sTM、ET-1、D-D的含量显著高于sTLT-1低含量的脑卒中患者。结论:缺血性脑卒中患者血清异常升高的HMGB1、sTLT-1能够引起氧化应激反应、内皮损伤加剧。
Objective:To study the correlation of serum HMGB1 and sTLT-1 contents with oxidative stress response and endothelial injury in patients with ischemic stroke.Methods:The patients who were diagnosed with ischemic stroke in Zhouzhi County People's Hospital between February 2015 and March 2017 were selected as the stroke group of the study,and healthy subjects who received physical examination during the same period were selected as the control group of the study.Serum was collected to determine the contents of HMGB1,sTLT-1,oxidative stress reaction molecules and endothelial injury molecules.Results:Serum HMGB1,sTLT-1,vWF,vWF-cp,sTM,ET-1,D-D,8-OHdG,LPO and NOS contents of stroke group were significantly higher than those of control group while T-SOD and GSH-Px contents were significantly lower than those of control group;serum T-SOD and GSH-Px contents of stroke patients with high HMGB-1 content were significantly lower than those of stroke patients with low HMGB-1 content while 8-OHdG,LPO and NOS contents were significantly higher than those of stroke patients with low HMGB-1 content;serum vWF,vWF-cp,sTM,ET-1 and D-D contents of stroke patients with high sTLT-1 content were significantly higher than those of stroke patients with low sTLT-1 content.Conclusion:The abnormally elevated HMGB1 and sTLT-1 in serum of patients with ischemic stroke can induce oxidative stress response and aggravate endothelial injury.
出处
《海南医学院学报》
CAS
2017年第21期3021-3024,共4页
Journal of Hainan Medical University
基金
陕西省科技厅基金项目(2014-D28)~~
关键词
缺血性脑卒中
高迁移率族蛋白1
髓样细胞触发受体样转录因子-1
氧化应激反应
内皮损伤
ischemic stroke
high mobility group box 1
triggering receptor expressed on myeloid cells-like transcript-1
oxidative stress response
endothelial injury
