摘要
目的观察和研究脊髓损伤后患者血清1型前胶原N端前肽(type 1 procollagen amino terminal peptide,P1NP)和血清1型胶原羧基末端肽(type 1 collagen carboxyl terminal peptide,β-CTX)的变化,以期提高临床对骨质疏松中骨转换标志物的认识,更好地指导临床工作。方法我院骨科自2012年10月至2014年12月收治颈脊髓损伤患者共69例,对所有患者均采集入院时及入院后2 w、4 w、8 w、12 w的静脉血,用电化学发光免疫分析检测血清P1NP和β-CTX水平,统计患者P1NP和β-CTX的数值,并进行前后比较、分析。结果入院时患者P1NP为(31.7±8.9)ng/mL,12 w后下降至(22.3±8.3)ng/mL,差异具有统计学意义(P<0.05);入院时患者β-CTX为(0.41±0.039)ng/mL,12 w后升高至(0.72±0.045)ng/mL,差异具有统计学意义(P<0.05);入院后2 w患者P1NP值较入院时提高,入院后2 w患者β-CTX值较入院时降低;入院时患者P1NP为(31.7±8.9)ng/mL,入院4w后P1NP为(30.3±8.1)ng/mL,差异无统计学意义(P>0.05);入院时患者β-CTX为(0.41±0.039)ng/mL,入院4 w后β-CTX为(0.40±0.052)ng/mL,差异无统计学意义(P>0.05)。P1NP测量值在2 w以后逐渐减少,以体质量指数(body mass index,BMI)小的患者为著;β-CTX测量值在2 w以后逐渐增大,以BMI小的患者为著;差异具有统计学意义(P<0.05)。结论颈脊髓损伤后检测P1NP及β-CTX值,可以准确地反映患者骨代谢情况,更好地预防骨质疏松。
Objective To observe and study the changes of P1NP and β-CTX in patients after cervical spinal injury, in order to improve the knowledge of osteoporosis bone turnover markers, and to guide clinical work. Methods In our hospital, 69 patients with cervical spinal cord injury were treated from October 2012 to December 2014. Venous blood of all the patients were collected after admission and 2, 4, 8, and 12 weeks after the admission. Serum P1NP and β-CTX levels were detected using luminescence immunoassay, and the results were analyzed and compared. Results P1NP in patients at admission was 31.7± 8.9 ng/mL. It decreased to 22.3± 8.3 ng/mL after 12 weeks, with statistical significance （P〈0.05）. β-CTX in patients at the admission was 0.41±0.039 ng/mL. It increased to 0.72 ± 0.045 ng/mL after 12 weeks, with statistical significance （P〈0.05）. P1NP value was higher 2 weeks after the admission but β -CTX was lower than that at the admission. P1NP was 31.7 ±8.9 ng/mL at admission, and it was 30.3± 8.1 ng/mL at 4 weeks after admission, with no significant difference （P〉0.05）. β-CTX in patients at the admission was 0.41± 0.039 ng/mL, and it was 0.40± 0.052 ng/mL 4 weeks after the admission, with no significant difference （P〉0.05）. P1NP decreased in 2 weeks, and it was more obvious in patients with smaller BMI. β-CTX increased gradually in 2 weeks, and it was more obvious in patients with smaller BMI. The difference was statistically significant （P〈0.05）. Conclusion Detection of P1NP and β-CTX after cervical spinal cord injury can reflect accurately the bone metabolism and can prevent osteoporosis in the patients.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2017年第12期1617-1620,共4页
Chinese Journal of Osteoporosis
