摘要
目的探讨血浆D-二聚体(D-Dimer)水平及血气分析(PaCO_2、PaO_2)在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压(PH)患者中的临床意义。方法选取我科135例AECOPD住院患者,分为2组:单纯AECOPD组(75例),AECOPD+PH组(60例),对所有入选患者进行血清D-Dimer及动脉血气分析检测。结果 AECOPD+PH组患者D-Dimer(0.76±0.18)μg/mL、PaCO_2(54.98±5.81)mm Hg,均高于AECOPD组的(0.36±0.11)μg/mL、(48.42±3.45)mm Hg,差异具有统计学意义(P<0.05);AECOPD+PH组患者PaO_2(63.1±8.06)mm Hg,低于AECOPD组的(69.49±7.5)mm Hg。多元线性回归分析结果显示,D-Dimer、PaCO_2水平与肺动脉收缩压呈正相关;PaO_2与肺动脉收缩压呈负相关。结论 D-Dimer参与了AECOPD合并肺动脉高压的形成,在AECOPD继发肺动脉高压的发病中具有重要作用。
Objective To observe the changes of D-Dimer and PaCO2、PaO2 in patients of the acute exacerbationof chronic obstructive pulmonary disease（AECOPD）with pulmonary hypertension（PH）.Methods One hundred andthirty five patients with AECOPD were measured pulmonary artery systolic pressure（PASP）by echocardiography. Theywere divided into 2 groups according to PASPpure AECOPD group 75 cases,AECOPD＋PH group 60 cases.SerumD-Dimer levels and arterial blood gas analysis were detected from all the selected patients.Results Serum D-Dimer,PaCO2 in AECOPD＋PH group[D-Dimer：（0.76±0.18）μg/mL,PaCO2：（54.98±5.81）mmHg] were significantly higherthan control AECOPD group[D-Dimer：（0.36±0.11）μg/mL,PaCO2：（48.42±3.45）mmHg];while PaO2[arterial partialpressure of oxygen：（63.1 ±8.06）mm Hg] were significantly lower than the control ones （69.49 ±7.5）mm Hg.Multivariate analysis showed that D-Dimer,PaCO2 have a significant positive linear relationship between PASP,whilePaO2 was negatively correlated with PASP.Conclusion The levels of D-Dimer are positively related to PH in AECOPDpatients,sμggesting that it plays a role in the pathogenesis of PH in AECOPD.
出处
《基层医学论坛》
2017年第34期4783-4785,共3页
The Medical Forum
关键词
慢性阻塞性肺疾病
肺动脉高压
D-二聚体
血气分析
Chronic obstructive pulmonary disease Pulmonary hypertension D-Dimer Arterial blood gasanalysis
