摘要
目的检测不同分期类风湿关节炎（eheumatoid arthritis，RA）患者外周血中辅助性T淋巴细胞17（T helper cell 17，Th17）的水平并探讨其临床意义。方法选择确诊的RA患者42例，其中活动期20例，非活动期22例，同时选择同期体检的健康人群25例设为对照，流式细胞仪与血清学检测各组人群的Th17细胞和CRP水平，并分析其相关性。结果活动期与非活动期RA患者外周血Th17细胞水平差异有统计学意义[ （1.92±2.6）%比（1.32±2.2）%，P〈0.05]；活动期或非活动期RA患者外周血Th17细胞水平与健康人群[（0.24±0.16）%]之间差异有统计学意义（P〈0.05），且外周血Th17细胞比例与机体炎症严重程度呈正相关性（r＝0.822，P〈0.05）。结论Th17细胞在RA的致病机制中发挥了重要作用，其动态检查对评估RA的发生发展具有临床意义。
Objective To explorethe clinical significance of T helper cell 17（Th17） cells levels in peripheral blood of patients with rheumatoid arthritis（RA） at different stages.Methods All 42 patients with RA were divided into active group（20） and inactive group（22 ）, at the same time, Meanwhile, 25 healthy examinees were selected as control group.The levevs of Th17 cells and C-reactive protein（CRP）were detected by flow cytometry and serological detection, analyze the correlation between the two group.Results There was the difference between the active group（1.92±2.6）% and inactive group（1.32±2.2）%（P〈0.05）, and there was also difference between patients group and control group（0.24±0.16）% （P〈0.05）. Th17 cells levels were related to the severity of inflammation（r=0.822, P〈0.05）.Conclusion Th17 cells may play an important role in the pathogenesisof RA, and the dynamic examination of Th17 has an important clinical significance.
作者
徐丹
Xu Dan(Department of Rheumatology,Xiaogan Central Hospital of Hubei Province ,Xiao gan 432000, Chin)
出处
《国际免疫学杂志》
CAS
2017年第6期655-658,共4页
International Journal of Immunology
