摘要
目的了解贵州医科大学附属医院2008-2016年阴沟肠杆菌的临床感染分布及耐药性变迁。方法采用WHONET 5.6软件回顾性分析各年阴沟肠杆菌的检出率、标本类型分布及耐药情况。结果2008-2016年共分离出2 009株阴沟肠杆菌,主要来源于痰液标本,占52.41%。药敏结果显示,阴沟肠杆菌对氨苄西林/舒巴坦的耐药率最高,对亚胺培南的耐药率最低。与2009年相比,2016年阴沟肠杆菌对氨苄西林/舒巴坦和亚胺培南之外的10种抗生素的耐药率均显著下降(P<0.05)。结论阴沟肠杆菌对临床常用抗生素的耐药率基本呈下降趋势,对碳青霉烯类抗生素耐药的阴沟肠杆菌应引起重视。
Objective To learn the distribution and change of drug resistance of E.cloacaeisolated from 2008 to 2016 in our hospital.Methods The detection rates,distribution of specimen type and drug resistance of E.cloacaein each year were retrospectively analyzed by using WHONET 5.6 software.Results A total of2,009 clinical strains of E.cloacae were isolated during 2008-2016.Most of the strains were isolated from sputum（52.41%）.The resistance rate of E.cloacae to Ampicillin/sulbactam was the highest,while the resistance rate to Imipenem was the lowest.Compared with 2009,the drug resistance rates of E.cloacaeto the other 10 antibacterial drugs except for Ampicillin/sulbactam and Imipenem had decreased significantly in2016（P〈0.05）.Conclusion The resistance rates of E.cloacae to commonly used antimicrobials tend to decrease,but the carbapenems-resistant E.cloacae should be monitored more closely.
出处
《中国微生态学杂志》
CAS
CSCD
2017年第11期1289-1293,共5页
Chinese Journal of Microecology
基金
贵阳市科技局科技计划项目[筑科合同(20151001)社34号]
关键词
阴沟肠杆菌
分布
耐药性
抗菌药物
Enterobactercloacae
Distribution
Drug resistance
Antibiotics
