摘要
目的了解医院2010年1月-2011年6月阴沟肠杆菌的临床分布及耐药性分析,为临床合理用药提供依据。方法从近年来感染标本中分离出阴沟肠杆菌,采用法国生物梅里埃公司VITEK-2Compact全自动细菌分析仪对所分离的菌株进行鉴定和药敏试验,采用WHONET5.4软件进行统计分析。结果分离的123株阴沟肠杆菌主要来自于肝胆外科、ICU等科室,标本主要来源于痰液、胆汁及尿液中;阴沟肠杆菌对亚胺培南、美罗培南、厄他培南、阿米卡星等有较好的抗菌活性,敏感率依次为99.19%、99.19%、94.31%、94.31%;而对头孢西丁、头孢唑林、氨苄西林/舒巴坦、头孢替坦、氨苄西林的敏感性较差,敏感率依次为1.63%、1.63%、4.88%、4.88%和4.07%。结论临床分离的阴沟肠杆菌耐药现象比较严重,应加强耐药性监测,以指导临床合理用药,控制医院感染。
OBJECTIVE To comprehend the clinical distribution and drug resistance of Enterobacter cloacae isolated from Jan 2010 to Jun 2011 so as to provide basis for the clinical reasonable use of antibiotics. METHODS The clinical specimens obtained in recent years were collected for E. cloacae isolation and the identification was conducted with automatic micro-bacteria verification analyzer, the drug susceptibility testing was carried out, and the statistical analysis was performed with WHONET 5. 4 software. RESULTS Of 123 strains of E. cloacae isolated,most of which were isolated from the hepatobiliary surgery department and ICU. The specimens were mainly obtained from the sputum, bile, and urine. The drug susceptibility testing showed that E. cloacae had good antibacterial activity against imipenem, meloxicam, ertapenem, and amikacin, with the drug susceptibility rates of 99.19% ,99.19% ,94.31 % ,and 94.31%, the drug susceptibility rates to cefoxitin, cefazolin, ampicillin/ sulbactam, cefotetan, and ampicillin were 1. 63%, 1. 63%, 4. 88%, 4. 88% , and 4. 07%, respectively. CONCLUSION The drug resistance of the clinical isolates of E. cloacae is serious, thus it is necessary to strengthen the monitoring of drug resistance so as to guide the clinical reasonable use of antibiotics and control the nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第1期187-189,共3页
Chinese Journal of Nosocomiology
关键词
阴沟肠杆菌
耐药率
医院感染
Enterobacter cloacae
Drug resistance rate
Nosocomial infection
