摘要
目的:研究含有不同促透剂的硝苯地平纳米乳(NFNE)的体外透皮吸收特性,为硝苯地平透皮制剂研发奠定基础。方法:采用Franz扩散池法,在硝苯地平纳米乳中添加油溶性的氮酮、油酸或者水溶性的季铵化程度不同的N-三甲基壳聚糖(TMC20、TMC40、TMC60)作为促透剂,考察其体外透皮特性。结果:硝苯地平纳米乳体外透皮效果优于硝苯地平(NF)。各促透剂对NFNE的促透效果顺序依次为:氮酮>油酸>TMC60>TMC40>TMC20,而水溶性促透剂起效较快。结论:硝苯地平纳米乳中脂溶性促透剂促透效果强,而水溶性促透剂起效较快。
Objective ： To study the in vitro transdermal permeability of nifedipine nanoemulsion （NFNE） containing different per- meation enhancers to lay foundation for the development of transdermal nifedipine preparation. Methods： Franz diffusion cells were used to study the transdermal enhancement of NFNE with different transdermal enhancers （ Azone, oleic acid, TMC20, TMC40, TMC60）. Results： The in vitro transdermal effect of NFNE was better than that of nifedipine （NF）. The order of in vitro transdermal permeation enhancement was as follows： azone 〉 oleic acid 〉 TMC60 〉 TMCA0 〉 TMC20, while the water-soluble transdermal permeation enhancers had faster effect. Conclusion： For NFNE, fat-soluble transdermal permeation enhancers have better effect.
出处
《中国药师》
CAS
2017年第12期2156-2159,共4页
China Pharmacist
关键词
硝苯地平纳米乳
体外透皮
促透剂
N-三甲基壳聚糖
Nifedipine nanoemulsion
In vitro transdermal experiment
Transdermal permeation enhancer
N-Trimethyl chitosan
