摘要
目的研究岩藻黄质软膏剂的最佳制备方法,确定最佳基质处方、成型工艺条件。方法以不同浓度的氮酮、丙二醇、油酸作为透皮促进剂,制备岩藻黄质软膏剂。采用改进的Franz直立式扩散池进行体外透皮实验,以离体的大鼠腹部皮肤作为透皮屏障,60%的乙醇-生理盐水作为接受介质,高效液相色谱法作为药物含量的测定方法,比较不同透皮促进剂下岩藻黄质的累积释放量(Q),扩散速率(J),以Q值和J值为指标,筛选投药量、透皮促进剂的种类(丙二醇、氮酮、油酸)和用量。结果不同吸收促进剂都能促进岩藻黄质的经皮吸收,其中以2%氮酮的透皮促进效果最佳。单位面积累积释放量24小时内提高至2.14倍,扩散速率(J)为1.85μg/(cm^2·h1/2)。结论岩藻黄质软膏剂可以开发为经皮给药制剂。
Objective To optimize the preparation method of fucoxanthine ointment and to determine its matrix formulation, mold- ing process conditions. Methods Fucoxanthine ointment was prepared with polyvinyl alcohol as matrix. With different concentra- tions of azone, propylene glycol, oleic acid mono and azone and other accelerator hyphenated as transdermal enhancer. The perme- ation flux of nimodipine through excised mice skin in vitro was determined using Franz diffusion cell, and with the mixture of 60% methanol - physiological saline as media. The content of nimodipine was measured by HPLC. Accumulative transdermal delivery of nimodipine（Q） and transdermal speed constant（J）were calculated. The loading amounts,type of transdermal enhancer（ propyl- ene glycol,azone and oleic acid）and their content were optimized with the value of Q and Js as index. Results Different transder- real enhancers were found to increase the percutaneous permeability of fueoxanthine ,2% azone as transdermal enhancers. The 24h accumulative infiltration quantity of fucoxanthine ointment was 2. 41 times that of the blank patch. Fucoxanthine ointment presen- ted high J of 1.85 μg cm-2 h-1 in 24h. Conclusion Fucoxanthine Ointment has good potential for transdermal delivery.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2017年第11期2639-2641,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(81573852)
关键词
岩藻黄质
软膏剂
透皮吸收
制备方法
Fucoxanthin
Ointment
Transdermal absorption
Preparation method
