摘要
基于层层组装技术,制备了能够长效释放抗癌药物甲氨蝶呤(MTX)的层层组装膜。分别通过聚天冬氨酸(PASP)和聚烯丙基胺盐酸盐-甲氨蝶呤(PAH-MTX)复合物基于静电作用的层层组装负载,以及先制备空白膜再后扩散负载这两种方法完成了MTX的膜内负载。层层组装负载中,聚电解质浓度增大则MTX负载量增多,当复合物pH=7.5时MTX的负载量较高且可持续释放36h。后扩散负载中,PASP-PAH/PAH空白膜与PASP/PAH及PASP/PAH-PASP空白膜相比,更有利于MTX的后扩散负载。后扩散负载与层层组装负载相比,药物负载量增多,但缓释时间降低。该研究为药物负载及缓释材料的制备提供了参考。
The Layer-by-layer polymeric films which was able to long lasting release anticancer drugs methotrexate disodium salt（MTX）were made based on electric attraction.MTX was loaded into the multilayer during the self-assemble procedure by incorporating drugs in the poly（allylamine hydrochloride）（PAH）solution via electrostatic interaction to produce PAH-MTX compound.Then PAH-MTX was alternately deposited with poly（aspartic acid）（PASP）to produce films.The load properties and release properties at different concentration of poly electrolyte and various PH conditions of PAH-MTX were studied,which showed that,the optimum pH values was 7.5 and the heighten the concentrations were,the more MTX loaded.MTX also can be loaded into PASP-PAH/PAH film by apost-diffusion process.The post-diffusion process of MTX loaded more drugs but released full faster than the loaded films during the self-assemble procedure.
出处
《化工新型材料》
CAS
CSCD
北大核心
2017年第11期160-164,共5页
New Chemical Materials
基金
国家自然基金青年基金项目(21304066)
山西省科技攻关项目(20100311117)
关键词
层层组装
药物负载
甲氨蝶呤
聚天冬氨酸
聚烯丙基胺盐酸盐
layer-by layer assembly, drug loading, methotrexate, poly （aspartic acid）, poly （allylamine hydrochloride）
