摘要
目的:系统评价真武汤治疗心肾阳虚型慢性心力衰竭的临床疗效。方法:计算机检索中国期刊全文数据库(CNKI),维普数据库(VIP),中国生物医学文摘数据库(CBM)和万方(Wanfang),Cochrane library,Pub Med等数据库,检索时限从2006年1月—2016年6月,手工检索相关杂志,搜集单纯西药常规与西药常规加真武汤及其加味方治疗心肾阳虚型慢性心力衰竭的随机对照试验,由Cochrane Handbook提供的方法评价纳入文献质量并提取有效数据进行Meta分析。结果:共纳入13个RCTs,总计851例样本,所纳入的文献质量普遍偏低。Meta分析结果显示:相比较对照组,治疗组在心功能疗效(OR=4.57,95%CI:[2.91,7.17],P<0.01)、中医证候积分(OR=-2.32,95%CI:[-3.30,-1.34],P<0.01)、心衰积分(OR=-1.61,95%CI:[-2.14,-1.08],P<0.01)、左室射血分数(OR=6.34,95%CI:[4.52,8.15],P<0.01)、N-末端B型脑钠肽(OR=-120.97,95%CI:[-158.85,-83.09],P<0.01)、脑钠利肽(OR=-122.41,95%CI:[-204.34,-40.49],P<0.01)、生存质量积分等指标优于单纯西医治疗,其差异均具有统计学意义(P<0.05)。结论:西医常规加用真武汤及其加味方优于单纯西医常规治疗,能进一步提高心肾阳虚型慢性心力衰竭的临床疗效。
Objective：To systematically evaluate the clinical curative effect of Zhenwu Decoction in treatment of heart and kidney yang deficiency syndrome of chronic heart failure. Methods ： We used computer to search the databases such as China journal full text database （CNKI）, VIP （VIP） database, Chinese Biomedical abstracts database （CBM） and Wanfang （Wanfang）, the Cochrane Library and PubMed database and the retrieval time from January 2006 to June 2016 and manually searched the related journals to collect the RCTS about treatment of simple western medicine and conven- tional western medicine routine plus Zhenwu Decoction and Decoction for heart and kidney yang deficiency syndrome of chronic heart failure. The method provided by Cochrane Handbook was used to evaluate the quality of the literature and extract the effective data for Meta- analysis. Results： A total of 13 RCTs, including a total of 851 samples,were collect- ed. The quality of the included literature was generally low. Meta - analysis results showed compared with the control group, the treatment group＇ s cardiac function （ OR = 4.57, 95% CI [ 2.91, 7.17 ], P 〈 0.01 ） effect, TCM syndrome integral （OR= -2.32, 95%CI [ -3.30, - 1.34], P〈0.01）, heart failure points （OR = - 1.61, 95%CI [ -2.14, - 1.08], P 〈 0. 01 ）, left ventricular ejection ejection fraction （ OR = 6.34, 95% CI [4.52, 8.15 ], P 〈 0.01 ）, N - terminal pro B - type natriuretie peptide （ OR = - 120.97, 95% CI [ - 158.85, - 83.09 ], P 〈 0. 01 ）, brain natriuretic peptide （ OR = - 122.41, 95% CI [ - 204.34, - 40.49 ], P 〈 0. 01 ） and quality of life score index were superior to that of simple western medicine treatment. The difference was statistically significant （ P 〈 0.05 ）. Con- clusion： Routine western medicine plus Zhenwu Decoction and its modified formula are superior to simple western medi- cine conventional therapy, and can further improve the clinical efficacy of heart and kidney yang deficiency syndrome of chronic heart
出处
《中华中医药学刊》
CAS
北大核心
2017年第12期3101-3106,共6页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81403381)
关键词
真武汤
心肾阳虚型
慢性心力衰竭
META分析
Zhenwu Decoction
heart kidney yang deficiency
chronic heart failure
Meta- analysis
