摘要
目的观察益智仁-乌药醚提取物对肾阳虚多尿模型大鼠的血环磷酸腺苷(c AMP)和醛固酮(ALD)水平的影响。方法应用腺嘌呤(250 mg/kg)造模,给予大鼠灌胃4 w,分别给予阳性对照药厄贝沙坦、益智仁-乌药醚提取物治疗4 w,观察益智仁-乌药醚提取物对大鼠c AMP和ALD的影响。结果与正常对照组比较,模型组大鼠血浆c AMP含量显著升高(P<0.01),血清ALD含量明显降低(P<0.01);益智仁-乌药醚提取物高剂量组血浆c AMP含量较模型组明显升高(P<0.05),血清ALD含量较模型组明显升高(P<0.05)。结论益智仁-乌药醚提取物能够提高肾阳虚多尿模型大鼠血浆c AMP和血清ALD水平。
Objective To observe the influence of ether extract of the Yizhiren-Wuyao on the levels of cyclic adenosine monophosphate（ c AMP）,aldosterone（ ALD） in polyuria model of Yang-deficiency rats. Methods The model rats were induced by given adenine（ 250 mg/kg）. After irrigation for 4 w,the levels of c AMP and ALD in the four groups were measured. Results Compared with those of normal control group,the c AMP level was significantly elevated,the ALD level was significantly decreased in model group（ P〈0. 01）; the levels of c AMP and ALD in Yizhiren-Wuyao high-dose group were significantly higher compared with those of model group（ P〈0. 05）. Conclusions Extract of the Yizhiren-Wuyao could increase plasma c AMP and ALD levels in polyuria model of yang-deficiency rats.
出处
《中国老年学杂志》
CAS
北大核心
2017年第22期5498-5499,共2页
Chinese Journal of Gerontology
基金
国家自然科学基金(81473618
81360586)
