摘要
目的 :研究强心贴联合氟伐他汀对心力衰竭合并糖尿病患者LVEF、NT-proBNP及TG的影响。方法 :选取于2014年5月—2016年7月收治的60例心力衰竭合并糖尿病的患者作为本次研究对象,按数字随机表法分为观察组和对照组。两组患者在入组后采取常规治疗,对照组服用氟伐他汀治疗;观察组在此基础上结合强心贴进行治疗。比较两组患者治疗后的临床疗效,并检测两组患者治疗前后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)和左室射血分数(LVEF);总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);血浆N末段脑钠肽(NT-proBNP)、糖化血红蛋白A1c(HbA1c)、C反应蛋白(CRP)水平。结果 :两组经治疗后观察组临床疗效明显优于对照组(P<0.05)。治疗后观察组LVEDD、LVESD明显低于对照组(P<0.05);LVEF明显高于对照组(P<0.05)。两组患者NT-proBNP、CRP、HbA1C、TG、TC水平经治疗均明显下降,观察组治疗后NT-proBNP、CRP、HbA1C、TG、TC水平明显低于对照组(P<0.05);HDL则明显高于对照组(P<0.05),两组治疗后LDL水平无显著差异(P>0.05)。结论 :强心贴联合氟伐他汀治疗心力衰竭合并糖尿病患者疗效确切,能显著改善患者LVEF、NT-proBNP及TG的水平。
Objective ：To study the effect of Qiangxin Paste combined with fluvastatin on LVEF,NT-proBNP and TG in patients with heart failure complicated with diabetes mellitus. Methods ：From May 2014 to July 2016,60 patients with heart failure complicated with diabetes in our hospital were selected as the research object,and were randomly divided into observation group and control group according to the random number table method. Two groups of patients in the group after the conventional treatment,the control group was treated with fluvastatin;On the basis of the observation group,the treatment was combined with strong heart paste. The clinical efficacy of the two groups were compared. Detected the level of Left ventricular end diastolic diameter（LVEDD）,left ventricular end systolic diameter（LVESD）and left ventricular ejection fraction（LVEF）;Total cholesterol（TC）,three acyl glycerol（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）;Plasma N terminal brain natriuretic peptide（NT-proBNP）,glycosylated hemoglobin A1c（HbA1c）,C reactive protein（CRP）before and after treatment in two groups.Results ：After treatment,the clinical efficacy of the two groups was significantly better than that of the control group（P0.05）. After treatment,the LVEDD and LVESD in the observation group were significantly lower than those in the control group（P0.05）;LVEF was significantly higher than that in the control group（P0.05）. Two groups of patients with NT-proBNP,CRP,HbA1 C,TG and TC levels after treatment were significantly decreased,NT-proBNP,CRP,HbA1 C,TG and TC levels after treatment in observation group was significantly lower than the control group（P0.05）;HDL was significantly higher than the control group（P0.05）,there was no significant difference between the two groups after treatment LDL levels（P0.05）. Conclusion ：The treatment of heart failure combined with diabetes mellitus is effective and can significantly improve the levels
出处
《辽宁中医药大学学报》
CAS
2017年第11期164-167,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2013257)
关键词
氟伐他汀
穴位敷贴
心力衰竭
糖尿病
fluvastatin
acupoint application
heart failure
diabetes
