摘要
柱晶白霉素酒石酸盐(白霉素)的剂型是粉针;溶解稀释供滴注用。应用微生物测定法对白霉素溶于5种输液经不同时间放置后进行测定,结果:(1)白霉素在复方乳酸钠葡萄糖注射液、复方电解质葡萄糖R2A注射液、乳酸钠林格氏注射液、复方乳酸钠山梨醇注射液及用NaHCO_3调节pH为7.0的10%葡萄糖注射液中稳定,经24h效价基本不下降。而在单纯的10%葡萄糖注射液中则稳定性略差;(2)白霉素在微弱碱性药液中较稳定。(3)白霉素的稳定性不受葡萄糖的影响(与红霉素不同)。
Kitasamycin was stable in compound sodiumlactate and glucose injection; compound glucose andelectrolytes R2A injection; lactated Ringer's injec-tion; sorbitol and lactated Ringer's injection and10% glucose injection after adjustion of pH to 7. 0by sodium bicarbonate injection within 24h, but itwas less stable in 10% glucose injection. Ki-tasamycin was comparatively stable in slightly alka-line solutions. The stability of kitasamycin was un-affected by presence of glucose, differing from thatof erytromycin.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1991年第8期476-477,共2页
Chinese Pharmaceutical Journal
关键词
柱晶白霉素
输液
稳定性
kitasamycin
iv infusion fluid
stability
antibiotic activity
