摘要
长期适宜强度的运动训练可诱导心脏重塑,主要表现为促进心肌细胞肥大和增殖、细胞存活、心肌血管再生、抑制心肌间质纤维化等一系列结构重塑,心脏产生适应性增大。虽已有较多研究探讨运动性心脏重塑的发生机制,但其至今尚不十分清楚。近年,研究人员通过基因芯片技术获得了运动性心脏重塑发生过程miRNA的表达图谱,部分研究通过功能获得和缺失方法进一步确认了关键miRNA,为研究运动性心脏重塑的调控机制提供了新的视角。另外,miRNA在运动性心脏重塑和病理性心脏重塑发生过程中表现出明显不同的变化特点,为运动性心脏重塑属生理性而非病理性重塑的阐释提供了新的证据。深入分析miRNA在运动性心脏重塑过程中的变化规律和作用机制,可为应用miRNA预防和治疗心脏疾病提供新的方法和策略。
Long-term moderate intensive training can induce cardiac remodeling,displaying cardiomyocyte hypertrophy and proliferation,cell survival,myocardial angiogenesis,inhibiting myocardial fibrosis and a series of structural remodeling with the adaptive cardiac enlargement. Although a lot of research has been carried out to explore the mechanism of exercise-induced cardiac remodeling,so far,it is not clear. In recent years,the researchers has obtained the expression profiles of micrornas in the process of exercise-induced cardiac remodeling with the help of gene chiptechnology. Some researchers confirmed the key microRNAs using the "gain and loss " method. miRNA provides a new perspective for the study of the regulation mechanism of exercise-induced cardiac remodeling. In addition,the miRNA showed varying characteristics between exercise-induced cardiac remodeling and pathological cardiac remodeling,thus providing a new evidence for physiologic remodeling interpretation of exercise-induced cardiac remodeling rather than pathological remodeling. The analysis of the changes and mechanism of miRNA in the process of exercise-induced cardiac remodeling can provide new methods and strategies for the prevention and treatment of cardiac diseases by miRNA.
出处
《体育科学》
CSSCI
北大核心
2017年第11期81-90,共10页
China Sport Science
基金
国家体育总局体育科学研究所基本科研业务经费(15-37)
关键词
运动
心脏重塑
细胞肥大
微小RNA
exercise
cardiac remodeling
cell hypertrophy
microRNA