摘要
目的:探讨血清半胱氨酸蛋白酶抑制剂C(sCys C)及β_2微球蛋白(β_2-MG)用于检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者肾损伤的临床意义。方法:随机选取OSAHS患者91例作为OSAHS组,健康成年人39例作为对照组。采用肌氨酸氧化酶法和谷氨酸脱氢酶法分别对血清尿素氮(BUN)、血清肌酐(Scr)进行检测。血清Cys C及β_2-MG采用免疫比浊法进行检测。结果:血清BUN、Scr在对照组和OSAHS各组间差异无统计学意义(P>0.05)。血清Cys C、β_2-MG在OSAHS组和对照组差异有统计学意义(P<0.01),血清Cys C、β_2-MG在OSAHS各水平组间差异有统计学意义(P<0.01)。结论:OSAHS早期可能引起肾功能隐匿性损伤,血清β_2-MG,sCys C的变化早于BUN、SCr水平的变化,提示血清Cys C、β_2-MG有望作为较早反映OSAHS早期肾功能损害的灵敏指标。
Objective： To observe the changes of serum Cystatin C（Cys C） and beta2-microglobulin（β2- MG） levels, and explore the relation between renal damage and levels of Cys C and β2-MG in pa- tients with obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods： Ninety-one patients with OSAHS were chosen randomly as OSAHS group. In addition, another 39 healthy adults were selected as control group. The levels of blood urea nitrogen（BUN） and serum creatinine （Scr） were determined by sarcosine oxidase and glutamate dehydrogenase, respectively, and Cys C and β2-MG were detected by immunonephelometry. Results： No difference was found between OSAHS group and control group in levels of SUN and Scr （P〉0.05）. The levels of Cys C and β2- MG in OSAHS group were significantly higher than those in the control group （P〈0.01）, and there were significant differences in Cys C and β2-MG levels among each OSAS subgroups. Conclusion： The levels of Cys C and 132 MG were increased significantly in OSAHS patients, sug-gesting that the renal function is easily impaired in patients with OSAHS. So Cys C and β2-MG may be the sensitive indicators that reflect earlier damage of renal function in OSAHS patients.
作者
张帆
袁琨
陈伟
蔡菁
ZHANG Fan;YUAN Kun;CHEN Wei;CAI Jing(The Central Hospital of Wuhan, Tongji Medical College ,Huazhong University of Science and Technology, Wuhan 430014 , China)
出处
《武汉大学学报（医学版）》
CAS
2017年第6期1002-1004,共3页
Medical Journal of Wuhan University
基金
武汉市卫生局资助项目(编号:WX11C08)
