摘要
由缺血再灌注(IR)引起的肝肾损伤的病因与许多介质有关,包括氧化产物、细胞因子和活性氧(ROS)。其中ROS在缺血再灌注损伤(IRI)的过程中起着至关重要的作用,参与许多病理过程如氧化应激、细胞凋亡等过程。锰(Ⅲ)-四(4-N-甲基吡啶基)卟啉(Mn(Ⅲ)TMPyP)作为超氧化物歧化酶(SOD)和过氧化氢酶(CAT)模拟物具有减轻IRI的潜力。本文就Mn(Ⅲ)TMPyP在缺血再灌注方面的研究作一综述。
The etiology of renal and hepatic injury due to ischemia-reperfusion （IR） is complexed with many mediators, including oxidant production, cytokines, and reactive oxygen species （ROS）. ROS play an important role in the process of ischemia-reperfusion injury（IRI）, and are involved in many pathological processes such as oxidative stress and apoptosis. Manganese （ Ⅲ ） tetrakis （1-methyl-4-pyridyl） porphyrin pentachloride （MnTmPyP）,acted as a mimics of superoxide dis mutase and catalase, has potential to reduce IRI. Here, we will briefly review the effect of MnT mPyP in the mechanisms of anti-IR injury.
作者
薛帅
兰佳男
胡前超
曾宪鹏
方泽鸿
熊艳
王彦峰
叶啟发
XUE Shuai;LAN Jianan;HU Qianchao;ZENG Xianpeng;FANG Zehong;XIONG Yan;WANG Yanfeng;YE Qifa(Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, ＆ Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071 , China;The 3rd Xiangya Hospital of Central South University ＆ Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha 410013, China)
出处
《武汉大学学报（医学版）》
CAS
2017年第6期890-895,共6页
Medical Journal of Wuhan University
基金
国家自然科学基金-新疆联合项目(编号:U1403222)
关键词
活性氧
锰卟啉
缺血再灌注
Reactive Oxygen Species
MnTmPyP
Ischemia-Reperfusion
