摘要
目的探讨神经元特异性烯醇化酶(NSE)在颅内感染患儿脑脊液和血清中含量变化及其对化脓性脑膜炎、病毒性脑膜炎的临床意义。方法选择该院2014年1月—2017年1月收治的颅内感染患儿50例与非神经系统感染患儿30例进行对照研究,其中50例颅内感染患儿又分为化脓性脑膜炎(28例)与病毒性脑膜炎(22例),所有患儿均进行脑脊液、血清可溶性白细胞介素2受体(SIL-2R)与NSE水平,并采取统计学分析对相关数据进行处理。结果三组患儿血清、脑脊液中SIL-2R与NSE水平与非神经系统感染患儿比较差异均有统计学意义(P<0.05),同时化脓性脑膜炎患儿血清与脑脊液中SIL-2R与NSE水平要显著高于病毒性脑膜炎患儿(P<0.05)。结论 NSE应用在颅内感染患儿脑脊液与血清中含量有一定差异,尤其是与非神经系统感染患儿相比差异明显,同时化脓性脑膜炎与病毒性脑膜炎患儿在脑脊液、血清中也存在NSE差异,从而可为临床诊断鉴别这二种疾病提供参考依据,值得借鉴。
Objective To investigate the changes of neuron specific enolase （NSE） in cerebrospinal fluid （CSF） and serum of children with intracranial infection and its clinical significance in purulent meningitis and viral meningitis.Methods From January 2014 to January 2017 in author＇s hospital,50 cases with intracranial infection and 30 cases with no nervous system infection were selected research subjects, and 50 cases of in- traeranial infection were divided into purulent meningitis （ 28 cases） and viral meningitis （22 cases ） , all pa- tients were treated with cerebrospinal fluid and serum soluble interleukin - 2 receptor （SIL- 2R） and the level of NSE.Results The serum and cerebrospinal fluid SIL - 2R and NSE levels in three groups and non nervous system infection in children showed no significant differences {P〈0.05）,while the level of SIL-2R and NSE in children with purulent meningitis was significantly higher than that in serum and cerebrospinal fluid in children with viral meningitis （P〈0.05）.Conclusion There are certain differences in the content of NSE in serum and cerebrospinal fluid in children with intracranial infection, especially in children with non nervous system infection differences, and purulent meningitis and viral meningitis there are also differences in NSE in the cerebrospinal fluid and serum, which can provide a reference for clinical diagnosis of these two dis- eases, worth reference.
出处
《中国煤炭工业医学杂志》
2017年第10期1193-1195,共3页
Chinese Journal of Coal Industry Medicine
关键词
颅内感染
NSE
脑脊液
血清
化脓性脑膜炎
病毒性脑膜炎
Intracranial infection
NSE
Cerebrospinal fluid
Serum
Purulent meningitis
Viral meningitis
