摘要
目的:探讨阿仑膦酸钠联合钙尔奇D对骨质疏松症患者疼痛和骨密度的影响。方法:选取2013年9月至2016年9月期间我院确诊治疗的骨质疏松症患者100例,依据随机双盲法分为联合组和常规组,每组50例,常规组患者给予常规饮食、运动等指导和300~600 mg·d^(-1)钙尔奇D口服治疗,每天1次,持续6个月,联合组患者在此基础上给予70 mg阿仑膦酸钠口服治疗,每周1次,持续6个月,采用视觉模拟评分法(VAS)评估疼痛程度,采用酶联免疫吸附法(ELISA)检测血清骨钙素(BGP)、碱性磷酸酶(ALP)、尿脱氧吡啶酚(DPD),采用Oswestry功能障碍指数问卷表(ODI)评估生活质量,随访6个月,统计分析所有患者临床疗效、治疗前后血清BGP、ALP、DPD水平、骨密度(腰椎L1~4、大粗隆)、疼痛和治疗前、治疗后1、3、6个月的生活质量及治疗期间不良反应发生情况。结果:联合组患者治疗有效率明显高于常规组,差异有统计学意义(P<0.05);联合组患者治疗后VAS得分明显低于常规组,前者治疗后腰椎L1~4、大粗隆骨密度明显高于后者,差异有统计学意义(P<0.05);联合组患者治疗后血清BGP水平明显高于常规组,前者治疗后血清ALP、DPD水平明显低于后者,差异有统计学意义(P<0.05);联合组患者治疗后1、3、6个月的ODI得分明显低于常规组,差异有统计学意义(P<0.05);联合组和常规组患者治疗期间均无明显的不良反应发生。结论:阿仑膦酸钠联合钙尔奇D治疗可有效提高骨质疏松症患者的治疗疗效,缓解患者的疼痛症状,改善患者的骨密度及骨代谢,有利于提高患者的生活质量,且具有良好的安全性。
Objective：To discuss the pain and bone mineral density effects of alendronate sodium combined with caltrate D for osteoporosis.Methods：100 patients with osteoporosis were selected from September 2013 to September 2016 in our hospital,according to the randomized double-blind,all patients were divided into combination group or conventional group,50 cases in each group,the conventional group of patients were given guidance in conventional diet,exercise and other aspects,with 300-600 mg＆#183;d-1 caltrate oral treatment,1 time＆#183;d-1,last for six months,the combination group of patients on the basis were given 70 mg of Allen phosphonic acid sodium oral treatment,1 time＆#183;week-1,last for six months.Visual analogue scale （VAS） was used to assess pain degree,e-linked immunosorbent （ELISA） was used to detect serum osteocalcin （BGP）,alkaline phosphatase （ALP） and urine deoxidization pyridine （DPD）,the Oswestry disability index questionnaire （ODI） was used to assess the quality of life.All patients were followed up for 6 months.Data analysis was conducted in efficacy,serum BGP,ALP,DPD level,bone density （lumbar L1-4,great tuberosity） before and after treatment,pain and treatment before and after treatment 1,3,6 months,the quality of life and treatment of adverse reactions occurred during the study.Results：The treatment efficiency rate of the combination group was significantly higher than that of the conventional group,there was statistically significant difference（P〈0.05）;The VAS score after treatment of the combination group was significantly lower than that of the conventional group,the lumbar L 1-4,great trochanter bone mineral density after treatment of the former were significantly higher than those of the latter,there were statistically significant difference（P〈0.05）;The serum BGP level after treatment of combination group was significantly higher than that of the conventional group,the serum ALP,DPD level after treatment of the former were significantly lower
出处
《临床药物治疗杂志》
2017年第6期39-43,共5页
Clinical Medication Journal
关键词
阿仑膦酸钠
钙尔奇D
骨质疏松症
疼痛
骨密度
alendronate sodium
caltrate D
osteoporosis
pain
bone mineral density
